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00920

Sigma-Aldrich

N-Acetyl-L-aspartic acid

≥99.0% (T)

Sinonimo/i:

(2S)-2-Acetamidobutanedioic acid, N-Acetyl-S-aspartic acid

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About This Item

Formula condensata:
HO2CCH2CH(NHCOCH3)CO2H
Numero CAS:
997-55-7
Peso molecolare:
175.14
Beilstein:
1726198
Numero MDL:
MFCD00020500
Codice UNSPSC:
12352209
eCl@ss:
32160406
ID PubChem:
329747163
NACRES:
NA.22

Livello qualitativo

100

Saggio

≥99.0% (T)

Forma fisica

powder

Attività ottica

[α]20/D +12±1°, c = 2% in 6 M HCl

Impiego in reazioni chimiche

reaction type: solution phase peptide synthesis

Colore

colorless to white

Punto di fusione

137-140 °C (lit.)
141-146 °C

applicazioni

peptide synthesis

Stringa SMILE

CC(=O)N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/t4-/m0/s1
OTCCIMWXFLJLIA-BYPYZUCNSA-N

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Categorie correlate

Applicazioni

N-Acetyl-L-aspartic acid can be used as a reactant to synthesize:
  • Protected homoserine γ-lactones by selective reduction and acid-catalyzed cyclization reaction.
  • Racemic amino substituted succinimide derivatives via cyclocondensation reaction.

Altre note

Review; acetyl donor in acetylcholine formation in brain.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
BCCG9464
BCCB2022
BCBR3519V
BCBL3992V
BCBG2051V

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Maria A Rocca et al.
NeuroImage, 18(4), 847-855 (2003-05-03)
Previous work has suggested that functional reorganization of cortical areas might have a role in limiting the clinical impact of axonal pathology in patients with established multiple sclerosis (MS). Since there is evidence for irreversible tissue damage even in patients
P Gideon et al.
Stroke, 23(11), 1566-1572 (1992-11-01)
The early time course after acute stroke of cerebral N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline was studied in vivo by means of localized water-suppressed proton magnetic resonance spectroscopy. Eight patients with acute stroke were studied serially in the
Emilie Chamard et al.
Neurosurgical focus, 33(6), E4: 1-E4: 7 (2012-12-04)
Despite negative neuroimaging findings using traditional neuroimaging methods such as MRI and CT, sports-related concussions have been shown to cause neurometabolic changes in both the acute and subacute phases of head injury. However, no prospective clinical study has used an
R. Bakhash et al.
Bios (Madison, N.J.), 49, 13-13 (1978)
E A Kvittingen et al.
Clinica chimica acta; international journal of clinical chemistry, 158(3), 217-227 (1986-08-15)
Excessive excretion of N-acetylaspartic acid in urine is reported in a 6-yr-old child with extensive and progressive cerebral atrophy. The concentration in urine was 947-1,433 mumol/mmol creatinine (controls, n = 10, 5-21 mumol/mmol creatinine) and the daily excretion approximately 3-4
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