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OP44

Sigma-Aldrich

Anti-APC (Ab-1) Mouse mAb (FE9)

liquid, clone FE9, Calbiochem®

Sinonimo/i:

Anti-Adenomatous Polyposis Coli

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.43

Origine biologica

mouse

Livello qualitativo

100

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

FE9, monoclonal

Forma fisica

liquid

contiene

≤0.1% sodium azide as preservative

Reattività contro le specie

rat, human, mouse

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

do not freeze

Isotipo

IgG1

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... APC(324)

Descrizione generale

Anti-APC (Ab-1), mouse monoclonal, clone FE9, recognizes full length APC (p300) in HCT116 cells and truncated APC (p147) in SW480 cells. It is validated for Western botting.
Protein G purified mouse monoclonal antibody generated by immunizing mice with the specified immunogen and fusing splenocytes with SP40 cells. Recognizes the ~300 kDa APC protein as well as a variety of truncated forms.
Recognizes full length APC (p300) in HCT116 cells and truncated APC (p147) in SW480 cells.
  • Antibody Target Gene Symbol: APC
  • Target Synonym: AI047805, Apc7, AU020952, AW124434, BTPS2, DP2, DP2.5, DP3, Familial adenomatous polyposis, FAP, GS, Min, RATAPC
  • Entrez Gene Name: adenomatous polyposis coli
  • Hu Entrez ID: 324 (Related Antibodies: OP80, ST1150, OP62, OP47L)
  • Mu Entrez ID: 11789
  • Rat Entrez ID: 24205

    • Immunogeno

    a synthetic peptide corresponding to the N-terminal 35 amino acids of APC

    Applicazioni

    Immunoblotting (1 µg/ml, see comments)

    Confezionamento

    Please refer to vial label for lot-specific concentration.

    Attenzione

    Toxicity: Standard Handling (A)

    Stato fisico

    In 50 mM sodium phosphate buffer, pH 7.5, 0.2% gelatin.

    Risultati analitici

    Positive Control
    HCT116 cells for p300, SW480 cells for truncated APC (p147)

    Altre note

    Koetsier, P. A., et al. 1993. BioTechniques15, 258.
    Smith, K. J., et al. 1993. Proc. Natl. Acad. Sci., USA90, 2846.
    Su, L.-K., et al. 1993. Can. Res.53, 2728.
    Boynton, R. F., et al. 1992. Proc. Natl. Acad. Sci. USA89, 3385.
    D′Amico, D., et al. 1992. Cancer Res.52, 1996.
    Fearon, E. R., and Jones, P. A., 1992. FASEB J.6, 2783.
    Miyoshi, Y., et al. 1992. Proc. Natl. Acad. Sci. USA89, 4452.
    Powell, S. M., et al. 1992. Nature359, 235.
    Groden, J., et al. 1991. Cell66, 589.
    Kinzler, K. W., et al. 1991. Science253, 661.
    Nishisho, I., et al. 1991. Science253, 665.

    Note legali

    CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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    Codice della classe di stoccaggio

    11 - Combustible Solids

    Classe di pericolosità dell'acqua (WGK)

    WGK 1

    Punto d’infiammabilità (°F)

    Not applicable

    Punto d’infiammabilità (°C)

    Not applicable

    Certificati d'analisi (COA)

    Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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    Mireia Menéndez et al.
    Gastroenterology, 134(1), 56-64 (2008-01-02)
    We identified the APC N1026S variant of unknown malignant potential in the adenomatous polyposis coli (APC) gene in a Spanish attenuated familial adenomatous polyposis (AFAP) family. The variant was located in the first of the 4 highly conserved 15-amino acid
    Tamar Evron et al.
    Oncogenesis, 10(9), 63-63 (2021-09-24)
    The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer, and is especially implicated in the development and progression of colorectal
    Hideaki Toki et al.
    Cancer science, 104(7), 937-944 (2013-04-05)
    Mutant mouse models are indispensable tools for clarifying the functions of genes and elucidating the underlying pathogenic mechanisms of human diseases. We carried out large-scale mutagenesis using the chemical mutagen N-ethyl-N-nitrosourea. One specific aim of our mutagenesis project was to
    Claudia Gaspar et al.
    PLoS genetics, 5(7), e1000547-e1000547 (2009-07-07)
    Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal adenomas and of a broad spectrum of extra-intestinal tumors. Moreover, somatic APC mutations
    Nathaniel S Rial et al.
    International journal of cancer, 124(10), 2270-2280 (2009-01-29)
    Elevated deoxycholic acid (DCA), mutations in the adenomatous polyposis coli (APC) gene and chronic inflammation are associated with increased risk of colorectal cancer. APC status was manipulated to determine whether DCA mediates inflammatory molecules in normal or initiated colonic mucosa.
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