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AB5423

Sigma-Aldrich

Anti-Tyrosine Hydroxylase Antibody, phosphoSer31

Chemicon®, from rabbit

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

affinity purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

rat

Produttore/marchio commerciale

Chemicon®

tecniche

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

N° accesso UniProt

Condizioni di spedizione

dry ice

modifica post-traduzionali bersaglio

phosphorylation (pSer31)

Informazioni sul gene

rat ... Th(25085)

Specificità

Tyrosine Hydroxylase, phosphoSer31. The antibody recognizes a protein of 60 kDa corresponding to TH phosphorylated at Ser31 in lysates of PC-12 cells stimulated by okadaic acid.

Immunogeno

Epitope: phosphoSer31
Synthetic peptide from the phosphoSer31 of rat Tyrosine Hydroxylase. Available as catalog number AG398

Applicazioni

Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
This Anti-Tyrosine Hydroxylase Antibody, phosphoSer31 is validated for use in IC, IH, WB for the detection of Tyrosine Hydroxylase.
Western blot: 1:1,000

Immunocytochemistry: 1:1,000

Immunohistochemistry: 1:1,000

Optimal working dilutions must be determined by the end user.

Stato fisico

Affinity purified immunoglobulin. Liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

Stoccaggio e stabilità

Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2


Certificati d'analisi (COA)

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Cristina Núñez et al.
Endocrinology, 148(12), 5780-5793 (2007-09-08)
Our previous studies have shown that naloxone-induced morphine withdrawal increases the hypothalamic-pituitary-adrenocortical (HPA) axis activity, which is dependent on a hyperactivity of noradrenergic pathways [nucleus tractus solitarius (NTS) A(2)] innervating the hypothalamic paraventricular nucleus (PVN). Short-term regulation of catecholamine biosynthesis
Cristina Núñez et al.
Endocrinology, 150(7), 3118-3127 (2009-01-31)
Chronic opiate exposure induces neurochemical adaptations in the noradrenergic system. Enhanced responsiveness of the hypothalamo-pituitary-adrenal axis after morphine withdrawal has been associated with hyperactivity of ascending noradrenergic input from the nucleus of the solitary tract (NTS-A(2)) cell group to the
Rubén García-Cabrerizo et al.
Addiction biology, 24(2), 239-250 (2017-12-29)
While prior studies have established various interacting mechanisms and neural consequences (i.e. monoaminergic nerve terminal damage) that might contribute to the adverse effects caused by methamphetamine administration, the precise mechanisms that mediate relapse during withdrawal remain unknown. This study evaluated
Claire B de La Serre et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 311(5), R930-R939 (2016-11-03)
Increased neuropeptide Y (NPY) gene expression in the dorsomedial hypothalamus (DMH) has been shown to cause hyperphagia, but the pathway underlying this effect remains less clear. Hypothalamic neural systems play a key role in the control of food intake, in
Tshianda N M Alerte et al.
Neuroscience letters, 435(1), 24-29 (2008-03-04)
Tyrosine hydroxylase (TH), the rate limiting enzyme in catecholamine synthesis, is frequently used as a marker of dopaminergic neuronal loss in animal models of Parkinson's disease (PD). We have been exploring the normal function of the PD-related protein alpha-synuclein (alpha-Syn)

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