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Merck
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AB2963

Sigma-Aldrich

Anti-MMP-3 Antibody, NT

from rabbit, purified by affinity chromatography

Sinonimo/i:

matrix metallopeptidase 3 (stromelysin 1, progelatinase), matrix metalloproteinase 3 (stromelysin 1, progelatinase), Matrix metalloproteinase-3, transin-1, proteoglycanase, stromelysin-1, Transin-13

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

rhesus macaque, human

Reattività contro le specie (prevista in base all’omologia)

chimpanzee (100% sequence homology), rhesus monkey (100% sequence homology)

Confezionamento

antibody small pack of 25 μg

tecniche

immunohistochemistry: suitable (paraffin)
western blot: suitable

N° accesso NCBI

NP_002413

N° accesso UniProt

P08254

Condizioni di spedizione

ambient

Temperatura di conservazione

2-8°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... MMP3(4314)

Descrizione generale

MMP-3 (matrix metalloproteinase-3), also known as stromelysin-1, is a member of the matrix metalloproteinase (MMP) family of zinc endopeptidases. MMP’s are required for removal of extracellular matrix machinery during embryo development, morphogenesis and tissue remodeling. Endogenous tissue inhibitors of metalloproteinases (TIMPs) are responsible for regulating MMP-3. Any disruption of this system can cause diseases such as arthritis, metastasis, atherosclerosis and tumor growth.

Specificità

Other homologies: Mouse and rat (64% sequence homology).
This antibody recognizes MMP-3 at the N-terminus.

Immunogeno

Epitope: N-terminus
KLH-conjugated linear peptide corresponding to human N-terminal MMP-3.

Applicazioni

Detect MMP-3 using this Anti-MMP-3 Antibody, N-terminus validated for use in WB, IH(P).
Immunohistochemistry Analysis: A 1:600 dilution from a previous lot detected MMP-3 in colorectal carcinoma and ductal carcinoma tissues.
Research Category
Cell Structure
Research Sub Category
MMPs & TIMPs

Qualità

Evaluated by Western Blot in PMA-treated HL-60 concentrated media.

Western Blot Analysis: 0.1-1 µg/mL of this antibody detects MMP-3 in 10 µg of PMA-treated HL-60 concentrated media.

Descrizione del bersaglio

~58 kDa observed.
An uncharacterized band may be seen at ~78 kDa

Linkage

Replaces: AB812

Stato fisico

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
PMA-treated HL-60 concentrated media

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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