AB1252
Anti-Cytochrome P450 Enzyme CYP2E1 Antibody
serum, Chemicon®
Sinonimo/i:
cytochrome P450 2E1, cytochrome P450, family 2, subfamily E, polypeptide 1, cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1, flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
serum
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Reattività contro le specie
rat, human, mouse
Produttore/marchio commerciale
Chemicon®
tecniche
immunohistochemistry: suitable
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... CYP2E1(1571)
mouse ... Cyp2E1(13106)
rat ... Cyp2E1(25086)
Categorie correlate
Descrizione generale
Cytochrome P450 (CYP) is a huge and diverse superfamily of hemoproteins. It metabolize the fatty acid arachidonic acid (AA) to regulators of vascular tone.
Most CYPs can metabolize multiple substrates, and can catalyze multiple reactions. This accounts for their central importance in metabolizing the extremely large number of endogenous and exogenous molecules. In the liver, these substrates include drugs and toxic compounds as well as metabolic products such as bilirubin (a breakdown product of hemoglobin). Cytochrome P450 enzymes are present in many other tissues of the body including the mucosa of the gastrointestinal tract, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. More than 7700 distinct CYP sequences are known as of September 2007.
Most CYPs can metabolize multiple substrates, and can catalyze multiple reactions. This accounts for their central importance in metabolizing the extremely large number of endogenous and exogenous molecules. In the liver, these substrates include drugs and toxic compounds as well as metabolic products such as bilirubin (a breakdown product of hemoglobin). Cytochrome P450 enzymes are present in many other tissues of the body including the mucosa of the gastrointestinal tract, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. More than 7700 distinct CYP sequences are known as of September 2007.
Specificità
Reacts with human and rat cytochrome P450 enzyme CYP2E1 in hepatic microsomal fractions. No cross-reactivity with other cytochrome P450 enzymes in these species.
Applicazioni
Anti-Cytochrome P450 Enzyme CYP2E1 Antibody is an antibody against Cytochrome P450 Enzyme CYP2E1 for use in IH & WB.
Immunohistochemistry:
A previous lot was used on formaldehyde treated and frozen sections.
Optimal working dilutions must be determined by end user.
A previous lot was used on formaldehyde treated and frozen sections.
Optimal working dilutions must be determined by end user.
Qualità
Evaluated by Western Blot on Human brain lysates.
Western Blot Analysis:
1:1000 dilution of this antibody detected Cytochrome P450 CYP2E1 on 10 μg of Human brain lysates.
Western Blot Analysis:
1:1000 dilution of this antibody detected Cytochrome P450 CYP2E1 on 10 μg of Human brain lysates.
Descrizione del bersaglio
57 kDa
Stato fisico
Rabbit polyclonal antiserum in buffer containing no preservative.
Risultati analitici
Control
Liver tissue.
Liver tissue.
Note legali
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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