654380

Tunicamycin

from Strepomyces lysosuperficus, ≥98% (A+B+C+D, HPLC), powder, N-acetylglucosamine transferase, Calbiochem

• Sinonimo/i: Tunicamycin, Streptomyces lysosuperficus
• Formula empirica (notazione di Hill): C₃₉H₆₄N₄O₁₆
• Numero CAS: 11089-65-9
• Peso molecolare: 844.94
• Numero MDL: MFCD00065709
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Nome del prodotto: Tunicamycin, Streptomyces lysosuperficus,
• Descrizione: Tunicamycin, Streptomyces lysosuperficus
• Livello qualitativo: 200
• Saggio: ≥98% (A+B+C+D, HPLC)
• Stato: powder
• Produttore/marchio commerciale: Calbiochem^®
• Solubilità: DMSO: 10 mg/mL; DMF: soluble; pyridine: soluble
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: N4(C=CC(=O)NC4=O)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C(O)C[C@H]2O[C@@H]([C@@H]([C@H]([C@H]2O)O)NC(=O)\C=C\CC(C)C)O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3NC(=O)C)O)O)CO
• InChI: 1S/C30H46N4O16/c1-11(2)5-4-6-16(38)32-19-23(43)20(40)14(47-29(19)50-28-18(31-12(3)36)22(42)21(41)15(10-35)48-28)9-13(37)26-24(44)25(45)27(49-26)34-8-7-17(39)33-30(34)46/h4,6-8,11,13-15,18-29,35,37,40-45H,5,9-10H2,1-3H3,(H,31,36)(H,32,38)(H,33,39,46)/b6-4+/t13?,14-,15-,18-,19-,20+,21-,22-,23-,24+,25-,26-,27-,28-,29-/m1/s1; ZHSGGJXRNHWHRS-PEALBESXSA-N

Descrizione

Descrizione generale

A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca²⁺ mobilization in cells. Also available as a 25 mM solution in DMSO (Cat. No. 504570).

A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca²⁺ mobilization in cells.

Azioni biochim/fisiol

Primary Target
N-linked glycosylation

Secondary Target
thrombin-induced Ca²⁺ mobilization in cells

Attenzione

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Nota sulla preparazione

Aqueous solutions can be prepared from DMSO stock solutions by diluting in H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0.

Ricostituzione

Aqueous solutions can be prepared from stock solutions in DMSO by diluting with H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0 (preferably >8.0).

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Altre note

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
Price, B.D., et al. 1992. J. Cell Physiol.152, 545.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300
• Consigli di prudenza: P264 - P270 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 1 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable