204878

Complement C1r, Human, Activated, Two-Chain Form

Complement C1r, Human, Activated, Two-Chain Form, CAS 80295-34-7, is a native, activated, C1r complement component.

• Sinonimo/i: Complement C1r, Human, Activated, Two-Chain Form
• Numero CAS: 80295-34-7
• Numero MDL: MFCD00270206
• Codice UNSPSC: 12352202
• NACRES: NA.25

Proprietà

• Livello qualitativo: 100
• Saggio: ≥90% (SDS-PAGE)
• Stato: liquid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; avoid repeated freeze/thaw cycles
• Impurezze: IgG, IgA, IgM, albumin, C1s, C4BP, C1-INH, trace
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −70°C

Descrizione

Descrizione generale

Native, human, activated, C1r complement component. Generally, non-activated form composed of a single-chain glycoprotein. Present in normal human serum at 34 µg/ml. Non-activated C1r is found in circulating blood plasma as a dimer that associates with one C1q molecule and two C1s molecules to form the first component of complement (C1). Ensuing C1q binding to the classical complement pathway activators, each C1r proenzyme monomer is activated by cleavage into two disulfide-linked fragments of M.W. 60,000 and 35,000. The 35,000 peptide contains C1r enzymatic active site. Activated C1r continues activation via the classical pathway by cleaving, and thus activating C1s.

Azioni biochim/fisiol

≥80% of C1r will bind with excess C1-INH

Confezionamento

Please refer to vial label for lot-specific concentration.

Attenzione

Toxicity: Standard Handling (A)

Stato fisico

In 140 mM NaCl, 10 mM imidazole, 2 mM EDTA, pH 7.4.

Nota sulla preparazione

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Ricostituzione

Following initial thaw, aliquot and freeze (-70°C).

Altre note

Villiers, C.L., et al. 1983. Biochem. J. 215, 369.
Ziccardi, R.J. and Cooper, N.R. 1976. J. Immunol. 116, 496.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable