169756

Antithrombin III, Human Plasma

Single-chain glycoprotein present in normal serum at about 23 mg/100 ml.

• Sinonimo/i: Antithrombin III, Human Plasma, ATIII, Heparin cofactor, Factor Xa inhibitor
• Numero CAS: 90170-80-2
• Numero MDL: MFCD00166632
• Codice UNSPSC: 12352202
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Forma fisica: solid
• Attività specifica: ≥5 units/mg protein
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Solubilità: water: soluble
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

Single chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.

Single-chain glycoprotein present in normal serum at about 23 mg/100 ml. Principal physiological inhibitor of thrombin. Present at higher levels in plasma than in serum because it complexes with thrombin during coagulation. Functions by inhibiting proteolytic enzymes involved in blood coagulation and fibrinolysis, including Factor Xa, plasmin, thrombin, and trypsin. Potency is strongly enhanced by heparin.

Azioni biochim/fisiol

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Attenzione

Toxicity: Standard Handling (A)

Definizione di unità

One unit is defined as the amount of antithrombin that will inhibit 1.0 unit of human plasma thrombin present in excess. Thrombin activity is measured using 500 µM tosyl-Gly-Pro-Arg-pNA as substrate in 100 mM Tris-HCl at 25°C, pH 8.2

Stato fisico

Lyophilized from 100 mM sodium citrate buffer, 20 mM Tris-HCl, pH 8.3.

Nota sulla preparazione

Please refer to label for lot-specific volume prior to lyophilization.

Risultati analitici

single band by SDS-PAGE

Altre note

Tsiang, M., et al. 1997. J. Biol. Chem. 272, 12024.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable