05-1144
Anti-Talin Antibody, CT, clone TD77
clone TD77, from mouse
Sinonimo/i:
talin 1
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
TD77, monoclonal
Reattività contro le specie
chicken, human, mouse
tecniche
immunohistochemistry: suitable (paraffin)
western blot: suitable
Isotipo
IgG1
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
chicken ... Tln1(395194)
human ... TLN1(7094)
mouse ... Tln1(21894)
Descrizione generale
Talin consisting of a 47-kDa N-terminal head domain (residues 1-433) and a 190-kDa
C-terminal rod domain (residues 434-2541), links integrins to the actin cytoskeleton.
C-terminal rod domain (residues 434-2541), links integrins to the actin cytoskeleton.
Specificità
Expected cross-reactivity in mouse and chicken.
Recognizes Human Talin, and cross reacts with Mouse and chicken Talin. The epitope recognized by this antibody is located within the C-terminal region of the protein (residues 2269-2541), which also contains an F-actin binding site homologous to that in the yeast actin-binding protein SIa2p.
Applicazioni
Detect Talin using this Anti-Talin Antibody, C-terminus, clone TD77 validated for use in WB, IH(P).
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Talin in human GI track tissue.
Qualità
Evaluated by Western Blot in Jurkat cell lysates.
Western Blot Analysis: A 1:500 dilution of this lot detected Talin in 10 ug of Jurkat lysates.
Western Blot Analysis: A 1:500 dilution of this lot detected Talin in 10 ug of Jurkat lysates.
Descrizione del bersaglio
270 kDa
Linkage
Replaces: MAB3264
Stato fisico
Format: Purified
Purified from Protein A Sepharose™ chromatography
Purified immunoglobulin from Protein A Sepharose™ chromatography. Liquid in 0.02M PBS pH 7.6, 0.25 M NaCl containing 0.1% sodium azide.
Stoccaggio e stabilità
Maintain between 2 and 8°C for 1 year after date of receipt.
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Note legali
Sepharose is a trademark of Cytiva
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Michèle Moes et al.
The Journal of biological chemistry, 282(23), 17280-17288 (2007-04-14)
Talin1 is a large cytoskeletal protein that links integrins to actin filaments through two distinct integrin binding sites, one present in the talin head domain (IBS1) necessary for integrin activation and a second (IBS2) that we have previously mapped to
Andreas Wortmann et al.
The Journal of biological chemistry, 286(49), 42303-42315 (2011-10-14)
Reciprocal interactions between Src family kinases (SFKs) and focal adhesion kinase (FAK) are critical during changes in cell attachment. Recently it has been recognized that another SFK substrate, CUB-domain-containing protein 1 (CDCP1), is differentially phosphorylated during these events. However, the
Yekaterina B Khotskaya et al.
Molecular carcinogenesis, 53(12), 1011-1026 (2013-09-04)
Metastatic dissemination is a multi-step process that depends on cancer cells' ability to respond to microenvironmental cues by adapting adhesion abilities and undergoing cytoskeletal rearrangement. Breast Cancer Metastasis Suppressor 1 (BRMS1) affects several steps of the metastatic cascade: it decreases
Michael C Schmid et al.
Nature communications, 13(1), 1768-1768 (2022-04-03)
Myeloid cells play key roles in cancer immune suppression and tumor progression. In response to tumor derived factors, circulating monocytes and granulocytes extravasate into the tumor parenchyma where they stimulate angiogenesis, immune suppression and tumor progression. Chemokines, cytokines and interleukins
Mayra Álvarez-Santos et al.
Journal of cellular biochemistry, 117(10), 2385-2396 (2016-03-13)
The extracellular domains of some membrane proteins can be shed from the cell. A similar phenomenon occurs with β1 integrins (α1β1 and α2β1) in guinea pig. The putative role of β1 integrin subunit alterations due to shedding in airway smooth
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