860063P

Milk SM

Avanti Research^™ - A Croda Brand

• Sinonimo/i: N-(tricosanoyl)-sphing-4-enine-1-phosphocholine
• Numero CAS: 475662-40-9
• Numero MDL: MFCD28143627
• Codice UNSPSC: 12352211
• NACRES: NA.25

Proprietà

• Descrizione: Sphingomyelin (Milk, Bovine)
• Saggio: >99% (TLC)
• Stato: powder
• Confezionamento: pkg of 1 × 200 mg (860063P-200mg); pkg of 1 × 25 mg (860063P-25mg)
• Produttore/marchio commerciale: Avanti Research^™ - A Croda Brand
• Tipo di lipide: sphingolipids
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCC)=O)COP([O-])(OCC[N+](C)(C)C)=O
• InChI: 1S/C46H93N2O6P/c1-6-8-10-12-14-16-18-20-21-22-23-24-25-26-28-30-32-34-36-38-40-46(50)47-44(43-54-55(51,52)53-42-41-48(3,4)5)45(49)39-37-35-33-31-29-27-19-17-15-13-11-9-7-2/h37,39,44-45,49H,6-36,38,40-43H2,1-5H3,(H-,47,50,51,52)/b39-37+/t44-,45+/m0/s1; SXZWBNWTCVLZJN-NMIJJABPSA-N

Descrizione

Descrizione generale

As a major constituent of cell membranes, sphingomyelin is found at particularly high concentrations in the membranes of nerve cells (in the myelin sheaths) and red blood cells. It was previously thought to have a purely structural role, similar to the function of phosphatidylcholine, through intermolecular interactions mediated by the 2-amide group, the 3-hydroxy group and the 4,5-trans double bond of the sphingoid base.[1] However, it is now appreciated that sphingomyelin has a high affinity for cholesterol and that these two lipids pack tightly into liquid-ordered domains among a liquid-disordered phase to form lipid rafts.[1] These membrane microdomains are thought to function as signaling platforms that regulate the localization and interactions of proteins. But sphingomyelin does not just influence signaling as a component of lipid rafts — it is also a precursor to ceramides and other sphingolipid metabolites that comprise the sphingomyelin cycle or sphingolipid network.[1]
Sphingomyelin and related lipids

Applicazioni

Milk SM has been used as a lipid standard.[2] It is also suitable for detecting ceramide in feces[3] and for differential scanning calorimetry.[4]

Confezionamento

5 mL Amber Glass Screw Cap Vial (860063P-200mg)

5 mL Amber Glass Screw Cap Vial (860063P-25mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids