857392O
Avanti
(R)-FTY720-OMe
(R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol, neat oil
Sinonimo/i:
(R)-FTY720-methyl ether; ROME
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About This Item
Formula empirica (notazione di Hill):
C20H35NO2
Numero CAS:
Peso molecolare:
321.50
Codice UNSPSC:
12352211
NACRES:
NA.25
Prodotti consigliati
Saggio
>99% (TLC)
Forma fisica
liquid
Confezionamento
pkg of 1 × 1 mg (857392O-1mg)
Produttore/marchio commerciale
Avanti Research™ - A Croda Brand 857392O
Tipo di lipide
sphingolipids
bioactive lipids
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Categorie correlate
Descrizione generale
(R)-FTY720-OMe is the analogue of FTY720.
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.
Azioni biochim/fisiol
(R)-FTY720-OMe helps to block DNA synthesis and actin rearrangement induced by sphingosine 1-phosphate (S1P) in MCF-7 breast cancer cells. It can also reduce sphingosine kinase 2 (SK2) expression and prevent DNA synthesis in HEK 293 cells. (R)-FTY720-OMe has anti-breast cancer potential.
Confezionamento
5 mL Amber Glass Screw Cap Vial (857392O-1mg)
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells
Lim KG, et al.
Cellular Signalling, 23(10), 1590-1595 (2011)
Francesca Tonelli et al.
British journal of pharmacology, 168(6), 1497-1505 (2012-11-02)
Sphingosine kinase catalyses the formation of sphingosine 1-phosphate and is linked with androgen receptor signalling in prostate cancer cells. Therefore, we investigated the effect of sphingosine kinase inhibitors on androgen receptor expression. Androgen-sensitive LNCaP cells were treated with SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole)
David G Watson et al.
Cellular signalling, 25(4), 1011-1017 (2013-01-15)
Two isoforms of sphingosine kinase, SK1 and SK2, catalyze the formation of the bioactive lipid sphingosine 1-phosphate (S1P) in mammalian cells. We have previously shown that treatment of androgen-sensitive LNCaP prostate cancer cells with a non-selective SK isoform inhibitor, 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole
Keng Gat Lim et al.
Cellular signalling, 23(10), 1590-1595 (2011-05-31)
Sphingosine kinase 2 (SK2) catalyses the conversion of sphingosine to the bioactive lipid sphingosine 1-phosphate (S1P). We report here, the stereospecific synthesis of an analogue of FTY720 called (R)-FTY720-OMe, which we show is a competitive inhibitor of SK2. (R)-FTY720-OMe failed
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