Journal of ovarian research, 6(1), 75-75 (2013-10-30)
Lysine-specific demethylase 1 (LSD1, also known as KDM1A and AOF2) is a chromatin-modifying activity that catalyzes the removal of methyl groups from lysine residues in histone and non-histone proteins, regulating gene transcription. LSD1 is overexpressed in several cancer types, and
The Journal of organic chemistry, 78(4), 1687-1692 (2013-02-01)
The reaction of propargylic carbonates with 4-hydroxy-2-pyrones in the presence of a palladium catalyst is described. By the choice of the reaction temperature, two types of the substituted furo[3,2-c]pyran-4-one derivatives were regioselectively synthesized, respectively.
Chemical communications (Cambridge, England), 48(73), 9189-9191 (2012-08-09)
A versatile and highly enantioselective chiral Brønsted acid-catalyzed allenylation of aldehydes with propargyl borolane is reported. The reaction is shown to be practical and quite general with a broad substrate scope covering aryl, heteroaryl, α,β-unsaturated, and aliphatic aldehydes.
Journal of the American Chemical Society, 134(27), 11146-11152 (2012-06-06)
(15)N-Propargylcholine has been synthesized and hydrogenated with para-H(2). Through the application of a field cycling procedure, parahydrogen spin order is transferred to the (15)N resonance. Among the different isomers formed upon hydrogenation of (15)N-propargylcholine, only the nontransposed derivative contributes to
Highly stereoselective synthesis of tertiary propargylic centers and their isomerization to enantiomerically enriched allenes.
José Luis García Ruano et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(32), 9775-9779 (2012-08-01)
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