779229

(2-Hydroxypropyl)-γ-cyclodextrin

Wacker Chemie AG

• Sinonimo/i: Cavasol^® W8 HP, HGC
• Numero CAS: 128446-34-4
• Numero MDL: MFCD16621721
• Codice UNSPSC: 12352201
• NACRES: NA.22

Proprietà

• Stato: powder
• Livello qualitativo: 200
• Produttore/marchio commerciale: Wacker Chemie AG
• Grado di funzionalizzazione: 0.5-0.7 molar substitution
• Impurezze: ≤0.1% propylene glycol (Ph Eur)
• Perdita: ≤10.0% loss on drying
• pH: 6-9 (2% in H₂O)
• Punto di fusione: 250 °C
• Stringa SMILE: O1[C@@H]2O[C@H]([C@H](O[C@@H]3O[C@H]([C@H](O[C@@H]4O[C@H]([C@H](O[C@@H]5O[C@H]([C@H](O[C@@H]6O[C@H]([C@H](O[C@@H]7O[C@H]([C@H](O[C@@H]8O[C@H]([C@H]1[C@H]([C@@H]8O)O)COCC(O)C)[C@H]([C@@H]7O)O)CO)[C@H]([C@@H]6O)O)COCC(O)C)[C@H]([C@@H]5O)O)CO)[C@H]([C@@H]4O)
• InChI: 1S/C51H88O38/c1-14(56)8-73-11-21-42-29(64)36(71)50(81-21)85-40-19(6-54)79-48(34(69)27(40)62)89-44-23(13-75-10-16(3)58)82-51(37(72)30(44)65)86-41-20(7-55)78-47(33(68)26(41)61)88-43-22(12-74-9-15(2)57)80-49(35(70)28(43)63)84-39-18(5-53)76-45(31(66)24(39)59)83-38-17(4-52)77-46(87-42)32(67)25(38)60/h14-72H,4-13H2,1-3H3/t14?,15?,16?,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1; ODLHGICHYURWBS-RYJYQAAZSA-N

Descrizione

Descrizione generale

(2-Hydroxypropyl)-γ-cyclodextrin (HP-β-CD) is a hydrophilic compound that can be used as a complexing agent to increase the aqueous solubility and dissolution rate of the drug molecule.[1][2]

Applicazioni

For R&D use

HP-β-CD can be utilized to improve the aqueous solubility and dissolution rate of zolpidem (ZP) upon complexation. ZP-HP-β-CD complexes showed improved ataxic activity.[1]
It is also used to enhance the wound healing property of curcumin by increasing the water solubility.[3]

Note legali

Cavasol is a registered trademark of Wacker Chemie AG

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable