426016

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione

99%

• Formula empirica (notazione di Hill): C₈H₅F₃O₃
• Numero CAS: 326-90-9
• Peso molecolare: 206.12
• Numero CE: 206-315-1
• Numero MDL: MFCD00020935
• Codice UNSPSC: 12352100
• ID PubChem: 24866679
• NACRES: NA.22

Proprietà

• Livello qualitativo: 100
• Saggio: 99%
• Stato: liquid
• Indice di rifrazione: n20/D 1.528 (lit.)
• P. ebollizione: 203 °C (lit.)
• Punto di fusione: 19-21 °C (lit.)
• Densità: 1.391 g/mL at 25 °C (lit.)
• Gruppo funzionale: fluoro; ketone
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: FC(F)(F)C(=O)CC(=O)c1ccco1
• InChI: 1S/C8H5F3O3/c9-8(10,11)7(13)4-5(12)6-2-1-3-14-6/h1-3H,4H2; OWLPCALGCHDBCN-UHFFFAOYSA-N

Descrizione

Descrizione generale

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (furoyltrifluoroacetone, FTFA) is a β-diketone. Its cytotoxic activity against human cultured tumor and normal cells has been evaluated.[1] Reports suggest that 4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione partially inhibits the oxidation of ferrocyanide in ETP (electron transport particles) isolated from beef heart mitochondria.[2] Its reaction with N,N,N′,N′-tetramethylalkyl diamines to form ionic adducts has been investigated.[3] The conformational analysis of the enol and keto form of FTFA has been reported.[4]

Applicazioni

4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (tfa) may be used in the following studies:

• As capping ligand in the synthesis of [Eu(tfa)₃]₂bpm complexes (bpm=2,2′-bipyrimidine).[5]
• As reagent in the multistep synthesis of [¹³CD₂]benzylamine.[6]
• As reagent in the synthesis of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives by reacting with corresponding benzofurazan oxides.[7]
• In the efficient syntheses of perfluoroalkyl substituted azoles.[8]
• Synthesis of 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives.[9]

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 188.6 °F - closed cup
• Punto d’infiammabilità (°C): 87 °C - closed cup
• Dispositivi di protezione individuale: Eyeshields, Gloves, type ABEK (EN14387) respirator filter