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Merck
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Documenti

335673

Sigma-Aldrich

1-Dodecyl-2-pyrrolidinone

99%

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About This Item

Formula empirica (notazione di Hill):
C16H31NO
Numero CAS:
2687-96-9
Peso molecolare:
253.42
Numero CE:
403-730-1
Numero MDL:
MFCD00075066
Codice UNSPSC:
12352100
ID PubChem:
24860339
NACRES:
NA.22

Saggio

99%

Forma fisica

viscous liquid

Indice di rifrazione

n20/D 1.466 (lit.)

P. eboll.

202-205 °C/11 mmHg (lit.)

Densità

0.89 g/mL at 25 °C (lit.)

Stringa SMILE

CCCCCCCCCCCCN1CCCC1=O

InChI

1S/C16H31NO/c1-2-3-4-5-6-7-8-9-10-11-14-17-15-12-13-16(17)18/h2-15H2,1H3
NJPQAIBZIHNJDO-UHFFFAOYSA-N

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Descrizione generale

1-Dodecyl-2-pyrrolidinone is an N-alkyl lactam and its reduction with LiH3BNMe2 to the corresponding amine has been reported. It is a potential melatonin-specific chemical penetration enhancer.

Applicazioni

1-Dodecyl-2-pyrrolidinone was used in the preparation of few-layered flakes of molybdenum disulfide (MoS2) via liquid phase exfoliation of bulk MoS2 powder.

Avvertenze

Danger

Indicazioni di pericolo

H314,H317,H410

Classi di pericolo

Aquatic Acute 1 - Aquatic Chronic 1 - Skin Corr. 1B - Skin Sens. 1

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

235.4 °F - closed cup

Punto d’infiammabilità (°C)

113 °C - closed cup

Dispositivi di protezione individuale

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificati d'analisi (COA)

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1-metil-2-pirrolidinone United States Pharmacopeia (USP) Reference Standard

USP

1437202

1-metil-2-pirrolidinone

N,N-dimetildodecilammina N-ossido BioXtra, ≥99.0% (NT)

Sigma-Aldrich

40234

N,N-dimetildodecilammina N-ossido

1-metil-2-pirrolidinone ACS reagent, ≥99.0%

Sigma-Aldrich

443778

1-metil-2-pirrolidinone

Vijay Krishna Rachakonda et al.
Pharmaceutical research, 25(11), 2697-2704 (2008-08-07)
A novel technique is presented for identifying potential chemical penetration enhancers (CPEs) based on changes in the electrical resistance of skin. Specifically, a multi-well resistance chamber was designed and constructed to facilitate more rapid determination of the effect of CPEs
J Nakamura et al.
Journal of pharmacobio-dynamics, 14(1), 1-8 (1991-01-01)
Anticonvulsant activity, degradation into gamma-aminobutyric acid (GABA), and concentration in brain of 1-dodecanoyl-2-pyrrolidinone (I), a lipophilic derivative of a lactam of GABA, were compared with those of N-dodecanoyl GABA (II) and 1-dodecyl-2-pyrrolidinone (III) to get information about their pharmacological mechanisms.
H Sasaki et al.
The Journal of pharmacy and pharmacology, 42(3), 196-199 (1990-03-01)
The enhancing effect of combining 1-methyl-2-pyrrolidone (MP) and 1-lauryl-2-pyrrolidone (LP) as the vehicles for transdermal penetration of phenolsulphonphthalein (phenol red) has been investigated by using an in-vitro technique with excised rat skin. LP had a higher enhancing effect on the
Andrew Winchester et al.
ACS applied materials & interfaces, 6(3), 2125-2130 (2014-01-22)
We report on the electrochemical charge storage behavior of few-layered flakes of molybdenum disulfide (MoS2) obtained by liquid phase exfoliation of bulk MoS2 powder in 1-dodecyl-2-pyrrolidinone. The specific capacitances of the exfoliated flakes obtained using a 6 M KOH aqueous
Srinivas S Godavarthy et al.
Journal of pharmaceutical sciences, 98(11), 4085-4099 (2009-08-22)
One promising way to breach the skin's natural barrier to drugs is by the application of chemicals called penetration enhancers. However, identifying potential enhancers is difficult and time consuming. We have developed a virtual screening algorithm for generating potential chemical
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