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258385

Sigma-Aldrich

Protoporphyrin IX disodium salt

≥90% (HPLC)

Sinonimo/i:

3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid disodium salt, Depocolin-S, Ooporphyrin disodium salt

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250 MG
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1 G
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5 G
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Cambia visualizzazione
250 MG
57,80 €
1 G
195,00 €
5 G
645,00 €

About This Item

Formula empirica (notazione di Hill):
C34H32N4Na2O4
Numero CAS:
Peso molecolare:
606.62
Beilstein:
5227034
Numero CE:
Numero MDL:
Codice UNSPSC:
12352103
ID PubChem:
NACRES:
NA.23

57,80 €


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Livello qualitativo

Saggio

≥90% (HPLC)

Stato

powder

λmax

406 nm

Temperatura di conservazione

2-8°C

Stringa SMILE

[Na+].[Na+].Cc1c(CCC([O-])=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC([O-])=O

InChI

1S/C34H34N4O4.2Na/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16,36-37H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);;/q;2*+1/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;
JZRNDUPVNXWZDY-HXFTUNQESA-L

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Applicazioni

Protoporphyrin disodium salt (PpIX) was used as a dye content for fluorescence spectroscopic characterization in a study. [1] The cytotoxic effect of PpIX on sarcoma 180 solid tumors cells was reported in a study. [2][3]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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Pan Wang et al.
Ultrasonics, 53(5), 935-942 (2013-02-19)
Protoporphyrin IX (PpIX) has been used as a sensitizer in photodynamic therapy (PDT) as well as in sonodynamic therapy (SDT). The photo-bleaching of PpIX has been well investigated in many experimental systems and some photo-products have also been identified in
Hirotsugu Kobuchi et al.
PloS one, 7(11), e50082-e50082 (2012-11-29)
Accumulation of protoporphyrin IX (PpIX) in malignant cells is the basis of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy. We studied the expression of proteins that possibly affect ALA-mediated PpIX accumulation, namely oligopeptide transporter-1 and -2, ferrochelatase and ATP-binding cassette transporter G2
Kana Unuma et al.
PloS one, 8(2), e56526-e56526 (2013-03-05)
Lipopolysaccharide (LPS)-induced myocardial dysfunction is caused, at least in part, by mitochondrial dysfunction. Mitochondrial dysfunction and the oxidative damage associated with it are scavenged through various cellular defense systems such as autophagy to prevent harmful effects. Our recent study has
Agata Nowak-Stępniowska et al.
Acta biochimica Polonica, 59(4), 603-611 (2012-11-29)
Mitochondria are cell energetic centers where ATP is produced. They also play a very important role in the PDT as intracellular sites of photosensitizer localization. Photosensitizers gathering in mitochondria (like porphyrin derivatives used in this work) are more effective in
Leng-Yin Wang et al.
Nanoscale, 5(1), 416-421 (2012-11-29)
Various nanocarriers for photosensitizers have been developed to solve the problems of limiting the clinical utility of photodynamic therapy (PDT); however, to date, no carriers capable of supplying oxygen have been reported. We reported the development of a novel system

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Domande

1–2 di 2 domande  
  1. To study interaction of porphyrin with a protein, how should a solution of this compound be made for flourescence quenching?

    1 risposta
    1. This is not an application that is tested internally, but there is evidence in literature (Iwunze MO. The fluorescence study of the quenching of nanoemulsion by protoporphyrin IX (PPIX). Material Sci & Eng. 2022;6(3):97‒99. DOI: 10.15406/mseij.2022.06.00185) that concentrations between 6.45 x 10-7 M to 3.24 x 10-6 M PPIX are effective for quenching. Another author describes the quenching of protein fluorescence by PPIX by using a solution concentration range of 1×10−5 M to 3×10−4 M excited at 280 nm and 1x10−5 M to 3×10−4 M excited at 295 nm (Characteristics of the Protoporphyrin IX Binding Sites on Human Serum Albumin Using Molecular Docking, Molecules 2016, 21(11), 1519).

      Utile?

  2. What is the water solubility of PPIX-disodium?

    1 risposta
    1. This chemical is known to be soluble in chloroform or methanol and slightly soluble in water. The concentration at which this product is solubilized is not determined.

      Utile?

Recensioni

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