P8293

Protoporphyrin IX

From Porcine, ≥95%, guanylyl cyclase activator, powder

• Sinonimo/i: 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid, Kammerer’s porphyrin, Ooporphyrin
• Formula empirica (notazione di Hill): C₃₄H₃₄N₄O₄
• Numero CAS: 553-12-8
• Peso molecolare: 562.66
• NACRES: NA.32
• PubChem Substance ID: 24278655
• UNSPSC Code: 41106305
• EC Number: 209-033-7
• MDL number: MFCD00151109
• Beilstein/REAXYS Number: 380795
• Form: powder
• Assay: ≥95%
• Solubility: DMF: methanol (1:1): soluble-10 mg/mL, dark red-brown
• Biological source: Porcine

Proprietà

• Nome del prodotto: Protoporphyrin IX, ≥95%
• biological source: Porcine
• Quality Segment: 100
• assay: ≥95%
• form: powder
• solubility: DMF: methanol (1:1): soluble-10 mg/mL, dark red-brown
• fluorescence: λ_ex 402 nm; λ_em 625 nm (bound to HRP), λ_ex 409 nm; λ_em 633 nm
• storage temp.: 2-8°C
• SMILES string: Cc1c(CCC(O)=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(O)=O
• InChI: 1S/C34H34N4O4/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25/h7-8,13-16,35,38H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42)/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-
• InChI key: KSFOVUSSGSKXFI-UJJXFSCMSA-N

Descrizione

General description

Protoporphyrin IX imparts red color to heme and is the major porphyrin in blood. It is synthesized from protoporphyrinogen IX in the presence of protoporphyrinogen IX oxidase.

Protoporphyrin IX belongs to the porphyrin family, which are a class of tetrapyrroles. It is the iron-free form of hemin and amphiphilic in nature. It is the precursor of heme in its biosynthetic pathway.

Application

Activates soluble guanylyl cyclase.

Protoporphyrin IX has been used:

• as a standard in protoporphyrin assays[1]
• in fluorescence spectra analysis
• to treat cells in cell culture to study heme-mediated ferroportin 1 transcription

Biochem/physiol Actions

Protoporphyrin IX levels are elevated in tumor cells due to metabolism anomalies compared to normal cells.

Protoporphyrin IX penetrates human erythrocytes and aids the release of oxygen from them. It forms complexes with myoglobin and hemoglobin. It is a photosensitizer used in the photodynamic therapy of cancer.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves