Passa al contenuto
Merck

GABBR2

gamma-aminobutyric acid (GABA) B receptor, 2

Sinonimi:
GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099
Specie:
ID UniProtKB:
ID gene:
  • Human(9568) Summary: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
  • Mouse(242425) gamma-aminobutyric acid (GABA) B receptor, 2
  • Rat(83633) gamma-aminobutyric acid (GABA) B receptor 2
  • domestic guinea pig(100170764) gamma-aminobutyric acid (GABA) B receptor, 2
  • naked mole-rat(101719923) gamma-aminobutyric acid (GABA) B receptor, 2
  • Horse(100063963) gamma-aminobutyric acid (GABA) B receptor, 2
  • sheep(101103544) gamma-aminobutyric acid (GABA) B receptor, 2
  • Domestic Rabbit(100346845) gamma-aminobutyric acid (GABA) B receptor, 2
  • domestic cat(101093058) gamma-aminobutyric acid (GABA) B receptor, 2
  • cow(517040) gamma-aminobutyric acid (GABA) B receptor, 2
  • dog(481627) gamma-aminobutyric acid (GABA) B receptor, 2
  • Zebrafish(560267) gamma-aminobutyric acid (GABA) B receptor, 2
  • chicken(420979) gamma-aminobutyric acid (GABA) B receptor, 2

Custom & Knockdown Gene Products

Small Molecule - Agonist

Numero di prodotto
Descrizione
Specie
Baclofen, Pharmaceutical Secondary Standard; Certified Reference Material,
Specie
human
Baclofen, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Baclofen, European Pharmacopoeia (EP) Reference Standard,
Specie
human
Baclofen, British Pharmacopoeia (BP) Reference Standard,
Specie
human
(±)-Baclofen, ≥98% (HPLC), solid,
Specie
human, rat

Small Molecule - Allosteric Modulator

Numero di prodotto
Descrizione
Specie
CGP-13501, ≥98% (HPLC), solid,
Specie
human

Small Molecule - Antagonist

Numero di prodotto
Descrizione
Specie
2-Hydroxysaclofen, ≥98% (TLC), solid,
Specie
human
Phaclofen, solid,
Specie
human
(±)-Baclofen, ≥98% (HPLC), solid,
Specie
human, rat
Saclofen, solid,
Specie
mouse, human, rat
γ-Aminobutyric acid, ≥99%,
Specie
human, rat

Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti GABBR2 Antibody, clone 23GB5500, Rabbit Monoclonal, clone 23GB5500, recombinant rabbit monoclonal, expressed in HEK293 cells,
Reattività con
human, rat
Applicazione
western blot
Anti-GABA B Receptor R2 Antibody, serum, from guinea pig,
Reattività con
bovine, canine, chimpanzee, horse, human, mouse, rat, rhesus macaque, rhesus monkey
Applicazione
immunohistochemistry
western blot
Anti-GABAB Receptor 2, affinity isolated antibody, lyophilized powder,
Reattività con
rat
Applicazione
western blot
Monoclonal Anti-Gaba-B Receptor 2 - Rpe antibody produced in mouse, clone S81-2, purified immunoglobulin,
Reattività con
human, mouse, rat
Applicazione
immunocytochemistry
immunohistochemistry

western blot
Anti-GABBR2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry

Small Molecule - Inhibitor

Numero di prodotto
Descrizione
Specie
NO-711 hydrochloride, ≥98% (HPLC),
Specie
human
(±)-Vigabatrin, ,
Specie
human

esiRNA

Numero di prodotto
Descrizione
Specie
MISSION® esiRNA, targeting human GABBR2,
Specie
human