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  • Alcohol mediated synthesis of 4-oxo-2-aryl-4H-chromene-3-carboxylate derivatives from 4-hydroxycoumarins.

Alcohol mediated synthesis of 4-oxo-2-aryl-4H-chromene-3-carboxylate derivatives from 4-hydroxycoumarins.

The Journal of organic chemistry (2012-07-20)
Manoj R Zanwar, Mustafa J Raihan, Sachin D Gawande, Veerababurao Kavala, Donala Janreddy, Chun-Wei Kuo, Ram Ambre, Ching-Fa Yao
KIVONAT

The unusual alcohol mediated formation of 4-oxo-2-aryl-4H-chromene-3-carboxylate (flavone-3-carboxylate) derivatives from 4-hydroxycoumarins and β-nitroalkenes in an alcoholic medium is described. The transformation occurs via the in situ formation of a Michael adduct, followed by the alkoxide ion mediated rearrangement of the intermediate. The effect of the different alcohol and nonalcohol media on the reaction was investigated.

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Termékleírás

Sigma-Aldrich
trans-4-Methyl-β-nitrostyrene, 98%
Sigma-Aldrich
4-Hydroxycoumarin, 98%