SAB4200398

Anti-TFRC antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Szinonimák: Anti-CD71, Anti-TFR, Anti-TFR1, Anti-TR, Anti-TRFR, Anti-Transferrin receptor (p90, CD71), Anti-Transferrin receptor protein 1, Anti-p90, AntiT9
• UNSPSC kód: 12352203
• NACRES: NA.41
• konjugátum: unconjugated
• application: IF; WB
• klón: polyclonal
• faj reaktivitás: mouse, rat, human
• citations: 10
• technika/technikák: indirect immunofluorescence: 10-20 μg/mL using rat NRK cells; western blot: 2.5-5.0 μg/mL using whole extracts of human U-2-OS and mouse Neuro-2a cells

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 200
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: buffered aqueous solution
• molekulatömeg: antigen ~90 kDa
• faj reaktivitás: mouse, rat, human
• koncentráció: ~1.0 mg/mL
• technika/technikák: indirect immunofluorescence: 10-20 μg/mL using rat NRK cells; western blot: 2.5-5.0 μg/mL using whole extracts of human U-2-OS and mouse Neuro-2a cells
• UniProt elérési szám: P02786
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... TFRC(7037) ; mouse ... Tfrc(22042) ; rat ... Tfrc(64678)

Leírás

Általános leírás

Transferrin receptor (TFRC), also known as p90, CD71, TFR and TFR1, is a transmembrane glycoprotein. It is composed of two disulphide-bonded sub-units, contains three N-linked glycan units and is post-translationally modified with phosphate and fatty acyl groups.

Immunogén

synthetic peptide corresponding to an internal sequence of human TFRC, conjugated to KLH

Alkalmazás

Anti-TFRC antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biokémiai/fiziológiai hatások

Transferrin receptor (TFRC) mediates cellular iron uptake. It binds iron bound transferrin on the cell surface, and the receptor ligand complex undergoes endocytosis via clathrin coated pits. Endosomal acidification leads to iron release, which is transported to the cytosol or to the mitochondria in erythroid cells. The apotransferrin receptor complex is then recycled to the cell surface, where the affinity of apotransferrin for TFRC drops, resulting in its dissociation. TFRC is necessary for development of erythrocytes and the nervous system.

Fizikai forma

solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable