Z-007

Zolpidem phenyl-4-carboxylic acid solution

500 μg/mL in acetonitrile: water (1:1), ampule of 1 mL, certified reference material, Cerilliant^®

• CAS-szám: 109461-65-6
• MDL-szám: MFCD18252339
• UNSPSC kód: 41116107
• PubChem Substance ID: 329831594
• NACRES: NA.24

Tulajdonságok

• grade: certified reference material
• Minőségi szint: 300
• form: liquid
• Jellemzők: Snap-N-Spike^®/Snap-N-Shoot^®
• kiszerelés: ampule of 1 mL
• gyártó/kereskedő neve: Cerilliant^®
• koncentráció: 500 μg/mL in acetonitrile: water (1:1)
• technika/technikák: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• alkalmazás(ok): clinical testing
• format: single component solution
• tárolási hőmérséklet: −20°C
• SMILES string: CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c3ccc(cc3)C(O)=O
• InChI: 1S/C19H19N3O3/c1-12-4-9-16-20-18(13-5-7-14(8-6-13)19(24)25)15(22(16)11-12)10-17(23)21(2)3/h4-9,11H,10H2,1-3H3,(H,24,25)
• Nemzetközi kémiai azonosító kulcs: FELZONDEFBLTSP-UHFFFAOYSA-N

Leírás

Általános leírás

Zolpidem Phenyl-4-carboxylic acid is the major urinary metabolite of zolpidem, accounting for 51% of an administered dose. Literature references indicate the metabolite can be found in urine for 2-3 days following ingestion of a single therapeutic dose of zolpidem. Zolpidem, marketed as Ambien^® or Stilnox^®, is a nonbenzodiazepine used for the short-term treatment of insomnia.

Alkalmazás

• Pharmacokinetics in forensic contexts: A study demonstrated the simultaneous analysis of Zolpidem and its metabolites, including Zolpidem phenyl-4-carboxylic acid, in postmortem urine, which is critical for forensic toxicology (Yamaguchi et al., 2023).



• Detection in hair samples: Research developed a sensitive LC-MS/MS method for detecting picogram levels of Zolpidem and its primary metabolites, such as Zolpidem phenyl-4-carboxylic acid, in hair, offering valuable insights for forensic and clinical investigations (Kim et al., 2021).



• Advanced analytical techniques: The determination of Zolpidem phenyl-4-carboxylic acid and Zolpidem 6-carboxylic acid in hair was achieved using gas chromatography-electron ionization-tandem mass spectrometry, enhancing the capabilities of toxicological analyses (Kwon et al., 2021).



• Pharmacokinetic profiling: A study on the pharmacokinetics of Zolpidem and Zolpidem phenyl-4-carboxylic acid in oral fluid post administration provided crucial data for understanding drug behavior in therapeutic monitoring (Feng et al., 2019).



• Forensic case study: An examination of a fatal zolpidem poisoning case highlighted the postmortem distribution and redistribution of Zolpidem and its predominant metabolite, Zolpidem phenyl-4-carboxylic acid, in body fluids and tissues, offering insights for forensic pathology (Hasegawa et al., 2018).

Jogi információk

Ambien is a registered trademark of Sanofi S.A.

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Stilnox is a registered trademark of Sanofi S.A.

Biztonsági adatok

• Piktogramok: GHS02,GHS07
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H225,H302,H319
• Óvintézkedésre vonatkozó mondatok: P210 - P233 - P240 - P241 - P301 + P312 - P305 + P351 + P338
• Veszélyességi osztályok: Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Tárolási osztály kódja: 3 - Flammable liquids
• WGK: WGK 2
• Lobbanási pont (F): 55.4 °F - closed cup
• Lobbanási pont (C): 13 °C - closed cup