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Surface charge switching nanoparticles for magnetic resonance imaging.

Surface charge switching nanoparticles for magnetic resonance imaging.

International journal of pharmaceutics (2014-05-27)

Dong Jin Lee, Young Taik Oh, Eun Seong Lee

摘要

In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe3O4-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.

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