- Tracking injectable microspheres in dynamic tissues with encapsulated superparamagnetic iron oxide nanoparticles.
Tracking injectable microspheres in dynamic tissues with encapsulated superparamagnetic iron oxide nanoparticles.
Macromolecular bioscience (2012-11-06)
Travelle Franklin-Ford, Nehal Shah, Ellen Leiferman, Connie S Chamberlain, Amish Raval, Ray Vanderby, William L Murphy
PMID23124987
摘要
Trackable spheres of similar size to those typically used for sustained protein delivery are prepared by incorporating superparamagnetic iron oxide (SPIO) nanoparticles into the core of poly(lactide-co-glycolide) microspheres. The visibility of injections in static and temporally in dynamic tissue systems is demonstrated. This method improves upon other, less sensitive imaging modalities in their ability to track injectable delivery systems. The results obtained confirm the localization of microspheres to the injected target area and highlight the novelty of tracking delivery vehicles for other applications.
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Sigma-Aldrich
Resomer® RG 504 H，聚（D,L-丙交酯-co-乙交酯）, acid terminated, lactide:glycolide 50:50, Mw 38,000-54,000
Sigma-Aldrich
Resomer® RG 503 H，聚(D,L-丙交酯-共-乙交酯), acid terminated, lactide:glycolide 50:50, Mw 24,000-38,000
Sigma-Aldrich
Resomer® RG 752 H，聚（D,L-丙交酯-co-乙交酯）, acid terminated, lactide:glycolide 75:25, Mw 4,000-15,000
Sigma-Aldrich
Resomer® RG 502，聚（D,L-丙交酯-co-乙交酯）, lactide:glycolide 50:50, ester terminated, Mw 7,000-17,000
Sigma-Aldrich
Resomer® RG 504，聚（D,L-丙交酯-co-乙交酯）, lactide:glycolide 50:50, ester terminated, Mw 38,000-54,000
Sigma-Aldrich
Resomer® RG 756 S，聚（D,L-丙交酯-co-乙交酯）, ester terminated, lactide:glycolide 75:25, Mw 76,000-115,000
Sigma-Aldrich
Resomer® RG 503，聚（D,L-丙交酯-co-乙交酯）, lactide:glycolide 50:50, ester terminated, Mw 24,000-38,000
Sigma-Aldrich
Resomer® RG 858 S，聚(D,L-丙交酯-共-乙交酯), ester terminated, lactide:glycolide 85:15, Mw 190,000-240,000