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739944

Sigma-Aldrich

Resomer® RG 504，聚（D,L-丙交酯-co-乙交酯）

lactide:glycolide 50:50, ester terminated, Mw 38,000-54,000

别名:

PLGA

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About This Item

线性分子式:
[C3H4O2]x[C2H2O2]y
CAS号:
26780-50-7
MDL號碼:
MFCD00131930
分類程式碼代碼:
12162002
NACRES:
NA.23

品質等級

100

形狀

amorphous

饋電比

lactide:glycolide 50:50

分子量

Mw 38,000-54,000

降解時間

<3 months

黏度

0.45-0.60 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

轉變溫度

Tg 46-50 °C

儲存溫度

2-8°C

SMILES 字串

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI 密鑰

LCSKNASZPVZHEG-UHFFFAOYSA-N

相关类别

應用

Resomer® RG 504, 聚（ᴅ,ʟ-丙交酯-co-乙交酯）可用于制备 聚合物纳米颗粒， 其是 天然抗癌物质的有效载体。

聚（D, L-丙交酯-co-乙交酯）微球可用于制造凝血酶的止血给药设备。

特點和優勢

控释生物活性剂，缝线和生物可吸收的植入装置

法律資訊

Evonik产品
RESOMER is a registered trademark of Evonik Rohm GmbH

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCV5199
BCCG8281
BCCG6077
BCCG3831
BCCF9087

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Ananthakrishnan Soundaram Jeevarathinam et al.
Angewandte Chemie (International ed. in English) (2019-12-17)
We report a new approach to monitor drug release from nanocarriers via a paclitaxel-methylene blue conjugate (PTX-MB) with redox activity. This construct is in a photoacoustically silent reduced state inside poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PTX-MB@PLGA NPs). During release, PTX-MB is
Vanna Sanna et al.
International journal of nanomedicine, 7, 5501-5516 (2012-10-25)
Resveratrol, like other natural polyphenols, is an extremely photosensitive compound with low chemical stability, which limits the therapeutic application of its beneficial effects. The development of innovative formulation strategies, able to overcome physicochemical and pharmacokinetic limitations of this compound, may
Shu-Chun Chuang et al.
Parasites & vectors, 6, 34-34 (2013-02-13)
Current development efforts of subunit vaccines against Toxoplasma gondii, the etiological agent of toxoplasmosis, have been focused mainly on tachyzoite surface antigen 1 (SAG1). Since microparticles made from poly (lactide-co-glycolide) (PLG) polymers have been developed as safe, potent adjuvants or
Mani Gajendiran et al.
Colloids and surfaces. B, Biointerfaces, 104, 107-115 (2013-01-10)
A series of biodegradable low molecular weight PLGA-PEG-PLGA tri-block copolymers have been synthesized in powder form. The anti-tuberculosis drug Isoniazid (INH) loaded polymeric core-shell nanoparticles (CSNPs) have been prepared by sonication followed by water-in-oil-in-water (w/o/w) double emulsification technique. The nanoparticles
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
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