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Merck

SML0295

Sigma-Aldrich

二氢杨梅素

≥98% (HPLC)

别名:

(2R,3R)-3,5,7-三羟基-2-(3,4,5-三羟基苯基)-2,3-二氢色-4-酮, 3,3′,4′,5,5′,7-六羟基黄烷酮, DHM, 蛇葡萄素

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About This Item

经验公式(希尔记法):
C15H12O8
CAS号:
分子量:
320.25
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

儲存條件

protect from light

顏色

white to beige

溶解度

DMSO: ≥5 mg/mL (warmed)

儲存溫度

−20°C

SMILES 字串

O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC(O)=C(C(O)=C3)O)[C@H]1O

InChI

1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1

InChI 密鑰

KJXSIXMJHKAJOD-LSDHHAIUSA-N

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一般說明

二氢杨梅素是显齿蛇葡萄中的主要类黄酮物质。

應用

二氢杨梅素已用于研究其对分化好的3T3-L1前脂肪细胞中的脂肪生成和葡萄糖摄取的影响。它还用于研究其抗肝癌细胞的抗肿瘤活性。

生化/生理作用

二氢杨梅素 (Ampelopsin) 是一种具有抗氧化和抗癌活性的黄烷醇。
二氢杨梅素 (Ampelopsin) 是一种具有抗氧化和抗癌活性的黄烷醇,具有抗酒精中毒作用。 它的抗酒精作用似乎是由于它在苯并二氮杂卓位点作为 GABA-A受体的正调节剂的作用。
二氢杨梅素具有抗炎作用。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Jun Zhou et al.
Journal of separation science, 34(2), 160-168 (2011-01-20)
A simple, rapid and specific method based on cloud-point extraction (CPE) was developed to determine ampelopsin in rat plasma after oral administration by reversed-phase high-performance liquid chromatography. The non-ionic surfactant Genapol X-080 was chosen as the extract solvent. Some important
Li-Ping Ruan et al.
Journal of pharmaceutical and biomedical analysis, 38(3), 457-464 (2005-06-01)
The aim of this study was to increase the solubility of ampelopsin (AMP) in water by two systems: solid dispersions with polyethylene glycol 6000 (PEG 6000) or polyvinylpyrrolidone K-30 (PVP K30) and inclusion complexes with beta-cyclodextrin (BCD) and hydroxypropyl-beta-cyclodextrin (HPBCD).
Scott A Snyder et al.
Nature, 474(7352), 461-466 (2011-06-24)
Although much attention has been devoted to resveratrol, a unique polyphenol produced by plants and credited as potentially being responsible for the 'French paradox'--the observation that French people have a relatively low incidence of coronary heart disease, even though their
Baolai Zhang et al.
Anti-cancer drugs, 23(6), 590-596 (2012-01-14)
The aim of this study was to establish xenograft models of tumor in mice bladder and evaluate the antitumor efficacy of ampelopsin sodium (Amp-Na). A total of 2×10 human bladder carcinoma EJ cells and murine sarcoma 180 cells were instilled
Jiantao Ye et al.
Planta medica, 74(3), 252-257 (2008-02-27)
Human immunodeficiency virus (HIV) infection can result in oxidative stress through production of reactive oxygen species (ROS). Simultaneously, oxidative stress is able to activate the replication of virus and lead to the apoptosis of T lymphocytes which is the defense

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