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生物源
mouse
品質等級
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
SH-B1, monoclonal
物種活性
cat, rabbit, porcine, bovine, rat, human
濃度
~1 mg/mL
技術
immunohistochemistry: 1.5-3 μg/mL using immunoperoxidase labeling of pronase digested, formalin-fixed, paraffin-embedded sections of rabbit tongue.
同型
IgG1
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... S100B(6285)
一般說明
S-100β是一种钙结合蛋白。它主要存在于后脑和脊髓的星形胶质细胞和神经元中。
单克隆抗-S-100(β-亚基)(小鼠IgG1同种型)来源于小鼠骨髓瘤细胞和免疫小鼠脾细胞融合产生的SH-B1杂交瘤。S-100是一组小的热不稳定性高酸性同型或异型二聚体钙结合蛋白。该蛋白质以S-100α和S-100β两种亚型存在,它们是大脑特有的。
免疫原
纯化牛脑S-100β
應用
小鼠抗S-100(β-亚基)单克隆抗体可用于:
- 免疫组化
- 酶联免疫吸附测定(ELISA)(非Ca2+离子依赖性)
- 免疫细胞化学免疫印迹
- 斑点杂交
- 免疫组织化学。
生化/生理作用
S-100β蛋白与突触蛋白、细胞骨架蛋白和细胞周期蛋白相互作用。另外,它可以调节神经胶质细胞和神经元细胞中的钙水平。它与神经元可塑性、星形胶质细胞增生和神经元细胞存活有关。S-100β与阿尔茨海默病和肌萎缩侧索硬化症有关。
S-100参与细胞生长调节、增加膜对阳离子的通透性、许多脑部疾病(包括精神分裂症)的炎症反应、刺激核仁RNA聚合酶活性和脂肪细胞中转运蛋白质和游离脂肪酸。S-100β组织分布可作为鉴别诊断肿瘤和增生过程的有用工具。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Neuroscience letters, 261(1-2), 25-28 (1999-03-19)
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