所有图片(1)
About This Item
经验公式（希尔记法）:
C14H14N4OS
CAS号:
分子量:
286.35
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
>98% (HPLC)
形狀
solid
顏色
off-white to tan
溶解度
DMSO: soluble >20 mg/mL
起源
GlaxoSmithKline
儲存溫度
2-8°C
SMILES 字串
Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1
InChI
1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
InChI 密鑰
USFUFHFQWXDVMH-UHFFFAOYSA-N
基因資訊
human ... DRD2(1813) , DRD3(1814) , DRD5(1816) , HTR1E(3354) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)
rat ... Adra1a(29412) , Gabra2(29706) , Htr1a(24473) , Htr2b(29581) , Htr3a(79246)
應用
SB 204741已被用作5-羟色胺受体2B（Htr2B）拮抗剂：
- 抑制Htr2b信号传导以测定其在三个月大的成年斑马鱼中肝星状细胞（HSC）活化的作用
- 在小鼠抑郁样行为研究中测试其对氟西汀效果的抑制作用
- 在小鼠中测试其减少舍曲林引起的抓挠行为的作用
生化／生理作用
SB 204741 减少脊柱C-纤维突触中低剂量丁丙诺啡引起的突触易化（synaptic facilitation）。
5-HT2B血清素受体拮抗剂。
特點和優勢
该化合物由 GlaxoSmithKline开发。想浏览其他制药公司开发的化合物和已批准药物/候选药物目录， 请单击此处。
法律資訊
根据GlaxoSmithKline的协议出售用于研究目的
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice.
Sang Hoon Lee et al.
The Journal of allergy and clinical immunology, 142(4), 1349-1352 (2018-06-20)
Xiaowei Li et al.
Frontiers in psychiatry, 9, 734-734 (2019-01-23)
The long-lasting loss of sleep is a generally acknowledged risk factor for the occurrence of major depressive disorder (MDD), whereas sleep abnormalities being a key clinic symptom of the MDD. In our previous work, we demonstrated that the sleep deprivation
Ercan Ozdemir et al.
Bioelectromagnetics, 40(5), 319-330 (2019-06-04)
Much evidence demonstrates the antinociceptive effect of magnetic fields (MFs). However, the analgesic action mechanism of the electromagnetic field (EMF) is not exactly understood. The aim of the present study was to investigate the effects of 5-HT1 and 5-HT2 receptor
Qiqi Yang et al.
Cellular and molecular gastroenterology and hepatology, 3(3), 484-499 (2017-05-04)
Hepatocellular carcinoma (HCC) occurs more frequently and aggressively in men than in women. Although sex hormones are believed to play a critical role in this disparity, the possible contribution of other factors largely is unknown. We aimed to investigate the
Annika Gocht et al.
Transplant immunology, 49, 43-53 (2018-04-13)
Cardiac allograft vasculopathy (CAV) is the main obstacle for long-term survival after heart transplantation. Alloimmune mediated chronic vascular rejection results in several mechanisms like platelet activation, immigration of inflammatory cells through the endothelial layer and proliferation and migration of smooth
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门