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N194

Sigma-Aldrich

NS-398

≥98% (HPLC), solid

别名:

N-[2-(环己氧基)-4-硝基苯基]甲磺酰胺

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About This Item

经验公式（希尔记法）:
C13H18N2O5S
CAS号:
123653-11-2
分子量:
314.36
MDL编号:
MFCD00882995
UNSPSC代码:
12352200
PubChem化学物质编号:
24897540
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

solid

颜色

off-white

mp

127-128 °C

溶解性

DMSO: >5 mg/mL
H2O: insoluble

SMILES字符串

CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O

InChI

1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3

InChI key

KTDZCOWXCWUPEO-UHFFFAOYSA-N

基因信息

human ... ALOX5(240) , CYP19A1(1588) , PTGS1(5742) , PTGS2(5743)
mouse ... Ptgs2(19225)

应用

NS-398作为环氧化酶2(COX2)抑制剂，已用于研究其：
  • 对斑马鱼胚胎心率的作用
  • 对大鼠心肌细胞凋亡和缺氧/复氧的作用
  • 对大鼠脂多糖(LPS)诱导厌食的作用

生化/生理作用

NS-398属于非甾体抗炎药(NSAID)。具有抗炎、镇痛和退烧作用。
选择性环加氧酶-2（COX-2）抑制剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000143800
0000143800
091M4603V
088K46122
088K46121

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N Futaki et al.
General pharmacology, 24(1), 105-110 (1993-01-01)
1. NS-398 (N-[2-cyclohexyloxy-4-nitrophenyl] methanesulfonamide) is a new non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. 2. The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac.
Jihye Jung et al.
Cells, 8(7) (2019-06-30)
The epithelial-mesenchymal transition (EMT) is important in organ fibrosis. We hypothesized that growth arrest-specific protein 6 (Gas6) and its underlying mechanisms play roles in the prevention of EMT in alveolar epithelial cells (ECs). In this study, to determine whether Gas6
Naomi C Boisvert et al.
Clinical science (London, England : 1979), 132(13), 1453-1470 (2018-05-10)
Neuronal ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that maintains intracellular ubiquitin pools and promotes axonal transport. Uchl1 deletion in mice leads to progressive axonal degeneration, affecting the dorsal root ganglion that harbors axons emanating to the kidney.
Hae-Jun Lee et al.
Phytotherapy research : PTR, 31(3), 475-487 (2017-01-28)
In this study, we investigated the antiinflammatory effects of ethanol extracts of Potentilla. supina Linne (EPS) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and septic mice. EPS suppressed LPS-induced nitric oxide, prostaglandin E
Pareena Chotjumlong et al.
Journal of innate immunity, 5(1), 72-83 (2012-10-26)
Periodontal disease is caused by microorganisms and host-derived inflammation involving increased cyclooxygenase-2 (COX-2) expression and prostaglandin E(2) (PGE(2)) production. We previously demonstrated that human β-defensin-3 induces COX-2 and PGE(2) in human gingival fibroblasts (HGFs). We, therefore, aimed to examine the
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