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一般說明
β-葡糖醛酸糖苷酶（GUSB）是一种溶酶体酶，存在于动物、植物和细菌中。这种糖苷外切酶在脾脏、肝脏和肾脏中的活性很高。牛肝β葡糖醛酸糖苷酶（BLG）是同源四聚体，分子量为290 kDa。
應用
β-葡萄糖醛酸酶在GUS测定中可用作报告基因以监测基因的表达。
β来自牛肝的-葡糖醛酸苷酶已被用于β-葡糖醛酸苷酶抑制试验，用于研究苦味叶下珠提取物和分离的活性成分对β-葡糖醛酸苷酶的抑制作用。它还被用于进行脱葡萄糖醛酸化。
生化／生理作用
β-葡糖醛酸糖苷酶（GUSB）缺乏会导致VII型粘多糖贮积症（MPSVII），从而导致溶酶体在大脑中的存储。类固醇激素的葡糖醛酸糖苷酶在组织中的整合β可以在GUSB的帮助下完成。
β-葡萄糖醛酸酶可催化复合碳水化合物的分解。在人体中，它可将结合胆红素转化为非结合的形式，使胆红素利于重吸收。
單位定義
在37℃，pH 5.0（30分钟检测）条件下，一个Sigma或改良的Fishman单位可每小时从酚酞葡糖苷酸中释放1.0 μg酚酞。
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1 - Skin Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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实验方案
酶促检测罗马蜗牛和牛肝脏来源ß-葡萄糖醛酸酶(EC 3.2.1.31)适用于可检测罗马蜗牛和牛肝脏来源ß-葡萄糖醛酸酶的所有产品。应由经过培训的分析服务实验室人员负责按照书面规定执行此程序。
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为了使用β-葡糖醛酸酶优化水解，必须对每种待分析的葡糖苷酸代谢物进行某些因素的评估，例如孵育时间、温度、水解pH、酶源和酶浓度。
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