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C0253

Sigma-Aldrich

苯丁酸氮芥

别名:

4- [双(2-氯乙基)氨基]苯丁酸, 4-(4-[2-(2-氯乙基)氨基]苯基)丁酸

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About This Item

经验公式（希尔记法）:
C14H19Cl2NO2
CAS号:
305-03-3
分子量:
304.21
Beilstein:
999011
EC號碼:
206-162-0
MDL號碼:
MFCD00021783
分類程式碼代碼:
12352200
PubChem物質ID:
24278287
NACRES:
NA.77

形狀

powder

品質等級

200

儲存溫度

2-8°C

SMILES 字串

OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl

InChI

1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

InChI 密鑰

JCKYGMPEJWAADB-UHFFFAOYSA-N

基因資訊

human ... CYP2D6(1565)

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應用

苯丁酸氮芥已：
  • 用作烷化剂/化疗剂，以研究其对小鼠淀粉样蛋白形成的抗炎作用
  • 用作阳性对照品，以测定白血病小鼠单核巨噬细胞的细胞毒性
  • 用作腺嘌呤特异性DNA烷基化试剂，以为HeLa S3细胞突变特异性DNA烷基化构建多功能共轭物（8950A-Chb(Cl/OH)）

生化／生理作用

苯丁酸氮芥是一种氮芥烷化剂可用作抗癌药物。苯丁酸氮芥可与细胞膜、RNA、DNA和蛋白质结合。它可通过DNA交联表现出抗炎和抗肿瘤活性。苯丁酸氮芥可通过p53-依赖机制显示对慢性淋巴细胞白血病（CLL）的治疗作用。

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF4436V
WXBF3026V
BCCH8961
BCCG4515
BCCD5718

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Qingyao Shou et al.
Journal of natural products, 76(7), 1384-1387 (2013-07-16)
Two novel alkaloids (parvifloranines A and B), possessing an unusual 11-carbon skeleton linked with amino acids, were isolated from Geijera parviflora, an endemic Australian Rutaceae. Their structures were elucidated by extensive spectroscopic measurements including 2D NMR analyses. Parvifloranine A was
Daniel Catovsky et al.
Clinical lymphoma, myeloma & leukemia, 11 Suppl 1, S2-S6 (2011-11-09)
Although chlorambucil has been used in the management of chronic lymphocytic leukemia (CLL) for 55 years, the optimal dose and treatment duration have not been established. We summarized data from 4 UK randomized CLL trials over the past 30 years
Palle J Pedersen et al.
Journal of medicinal chemistry, 52(10), 3408-3415 (2009-05-01)
The synthesis and biophysical characterization of four prodrug ether phospholipid conjugates are described. The lipids are prepared from the anticancer drug chlorambucil and have C16 and C18 ether chains with phosphatidylcholine or phosphatidylglycerol headgroups. All four prodrugs have the ability
C Muller et al.
Blood, 92(7), 2213-2219 (1998-09-25)
The objective of this study is to investigate the role of DNA-dependent protein kinase (DNA-PK) in the chronic lymphocytic leukemia (CLL) lymphocyte response to nitrogen mustard therapy. DNA-PK is a nuclear serine/threonine kinase that functions in DNA double-strand break repair
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Angewandte Chemie (International ed. in English), 55(13), 4194-4198 (2016-02-27)
Among the well-known phototriggers, the p-hydroxyphenacyl (pHP) group has consistently enabled the very fast, efficient, and high-conversion release of active molecules. Despite this unique behavior, the pHP group has been ignored as a delivery agent, particularly in the area of
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