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Merck
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文件

B2515

Sigma-Aldrich

L-丁硫氨酸亚砜亚胺

≥97% (TLC)

别名:

L-BSO

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About This Item

经验公式（希尔记法）:
C8H18N2O3S
CAS号:
83730-53-4
分子量:
222.31
Beilstein:
2367136
MDL號碼:
MFCD00067000
分類程式碼代碼:
12352202
PubChem物質ID:
24278263
NACRES:
NA.77

生物源

synthetic (organic)

化驗

≥97% (TLC)

形狀

powder

mp

224-226  °C

溶解度

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

CCCCS(=N)(=O)CC[C@H](N)C(O)=O

InChI

1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1

InChI 密鑰

KJQFBVYMGADDTQ-CVSPRKDYSA-N

基因資訊

human ... GCLC(2729) , GCLM(2730)

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應用

L丁硫氨酸-亚砜亚胺已用作：
  • 选择性激活剂，以诱导大鼠凋亡细胞的铁死亡
  • γ谷氨酰半胱氨酸合成酶抑制剂，以研究其对小黑麦和大麦小孢子胚胎发生（ME）诱导活力和效果的影响
  • 谷胱甘肽合成阻断剂，以研究其在小鼠肺泡巨噬细胞中金诺芬（AFN）介导的白介素-1β表达的影响

用于诱导实验性谷胱甘肽缺乏，以研究谷胱甘肽在细胞过程中的作用。

生化／生理作用

通过抑制谷胱甘肽生物合成中的关键酶γ-谷氨酰半胱氨酸合成酶，进而阻断对化疗的细胞抵抗性。用于诱导实验性谷胱甘肽缺乏，以研究谷胱甘肽在细胞过程中的作用。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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