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生物源
synthetic
化驗
≥99.0% (TLC)
形狀
powder or crystals
mp
215 °C
溶解度
H2O: 50 mg/mL, clear to almost clear, colorless
儲存溫度
2-8°C
SMILES 字串
CCCCS(=N)(=O)CCC(N)C(O)=O
InChI
1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
InChI 密鑰
KJQFBVYMGADDTQ-UHFFFAOYSA-N
應用
DL-丁硫氨酸-亚砜亚胺适用于：
- 检测 BSO 抑制谷胱甘肽是否增强雌激素对抗激素抵抗性人乳腺癌细胞的凋亡作用
- 研究 BSO 对牛胚胎发育的影响
- 在多项研究中抑制 GSH
- GSH 合成对卵母细胞成熟的影响
生化／生理作用
丁硫氨酸亚砜亚胺抑制肝脏和其他外周器官谷胱甘肽 (GSH) 的生物合成。对 CNS 中 GSH 无任何影响。增强活性氧（如过氧化氢）和间接引起活性氧蓄积的药物（如 2-甲氧基雌二醇，增加细胞内超氧阴离子）操作抗增殖作用。
其他說明
耗尽分离细胞中的谷胱甘肽
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Yuka Hirai et al.
Biological & pharmaceutical bulletin, 29(5), 1064-1067 (2006-05-03)
2-Methoxyestradiol (2-ME), an endogenous metabolite of 17beta-estradiol, induces the intracellular accumulation of superoxide anion (O2*-) and buthionine sulfoximine (BSO) is an inhibitor of glutathione (GSH) synthesis. We have examined the combination anticancer effect of 2-ME and BSO accompanied with hydrogen
M A Baker et al.
Analytical biochemistry, 190(2), 360-365 (1990-11-01)
By combining the least complicated and expedient methods of sample handling with the sensitivity and specificity of the GSH assay by enzymatic recycling and the small volumes and software capabilities of microtiter plate technology we have devised a rapid, sensitive
A Slivka et al.
Journal of neurochemistry, 50(5), 1391-1393 (1988-05-01)
Previous studies indicated that DL-buthionine sulfoximine (DL-BSO), an agent that inhibits the biosynthesis of GSH in liver and other peripheral organs, fails to suppress levels of GSH in the CNS. In the current study, preweanling mice responded to repeated injections
Evaluation of hepatotoxicity and nephrotoxicity of natural food colorants in mice depleted of glutathione by DL-buthionine sulfoximine.
Kawazoe S, et al.
Journal of Health Science, 46, 56- 58 (2000)
Joan S Lewis-Wambi et al.
Breast cancer research : BCR, 10(6), R104-R104 (2008-12-09)
Estrogen deprivation using aromatase inhibitors is one of the standard treatments for postmenopausal women with estrogen receptor (ER)-positive breast cancer. However, one of the consequences of prolonged estrogen suppression is acquired drug resistance. Our group is interested in studying antihormone
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