所有图片(4)
About This Item
经验公式（希尔记法）:
C10H11N5NaO6P · H2O
CAS号:
分子量:
369.20
Beilstein:
54612
MDL號碼:
分類程式碼代碼:
41106305
eCl@ss:
32160414
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
≥98.0% (HPLC)
形狀
powder
顏色
white
溶解度
H2O: 10 mg/mL
儲存溫度
−20°C
SMILES 字串
[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O
InChI
1S/C10H12N5O6P.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
InChI 密鑰
BXJBFCKTIWRKMQ-MCDZGGTQSA-M
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相关类别
應用
腺苷-3′,5′-环磷酸(cAMP) 是环腺苷酸依赖性蛋白激酶A（PKA）的激活剂。 已有研究表明cAMP/PKA信号传导途径能够抑制细胞增殖、诱导分化并导致细胞凋亡。 外源性cAMP在心肌的自发性活动和收缩中发挥作用。
生化／生理作用
环化腺苷酸依赖性蛋白激酶 (PKA) 的自然活化剂。cAMP 是一种重要的第二信使，并且在很多系统中与神经递质或激素诱导的受体激活相关。已有显示，cAMP/PKA 信号通路可抑制细胞增殖，诱导分化并导致细胞凋亡。
特點和優勢
该化合物是环核苷酸研究推荐产品。点击此处 ，查看更多环核苷酸精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
W Tuganowski et al.
Polish journal of pharmacology and pharmacy, 30(4), 451-454 (1978-07-01)
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The filamentous fungus Neurospora crassa decomposes lignocellulosic biomass to generate soluble sugars as carbon sources. In this study, we investigated a role for heterotrimeric G-protein signaling in cellulose degradation. Loss of the Gα subunit genes gna-1 and gna-3, the Gβ
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Endothelial tight and adherens junctions control a variety of physiological processes like adhesion, paracellular transport of solutes or trafficking of activated leukocytes. Formation and maintenance of endothelial junctions largely depend on the microenvironment of the specific vascular bed and on
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Experimental cell research, 315(1), 26-38 (2008-10-28)
Dictyostelium atg1- mutant cells provide an experimentally and genetically favorable model to study necrotic cell death (NCD) with no interference from apoptosis or autophagy. In such cells subjected to starvation and cAMP, induction by the differentiation-inducing factor DIF or by
Connor M Blair et al.
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Cyclic nucleotide degrading phosphodiesterase (PDE) enzymes are crucial to the fine tuning of cAMP signaling responses, playing a pivotal role in regulating the temporal and spatial characteristics of discrete cAMP nanodomains and hence the activity of cAMP-effector proteins. As a
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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