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Merck

A6608

Sigma-Aldrich

白蛋白 人

recombinant, expressed in Saccharomyces cerevisiae, aqueous solution, 10% in aqueous buffer, ≥99% (agarose gel electrophoresis)

别名:

rHSA

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About This Item

经验公式(希尔记法):
C2936H4624N786O889S41
CAS号:
分子量:
66471.53
MDL號碼:
分類程式碼代碼:
12352202
eCl@ss:
42010201
NACRES:
NA.25

生物源

human

重組細胞

expressed in Saccharomyces cerevisiae

化驗

≥99% (agarose gel electrophoresis)

形狀

aqueous solution

分子量

monomer ~67 kDa

濃度

10% in aqueous buffer

技術

cell culture | mammalian: suitable

UniProt登錄號

儲存溫度

2-8°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI 密鑰

QYSGYZVSCZSLHT-UHFFFAOYSA-N

基因資訊

human ... ALB(213)

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一般說明

Albumin constitutes 25% of the proteins produced by the liver and is a prominent protein found in the blood. It is a protein of a single polypeptide chain with a thiol group.

應用

该重组变异建议用于:吸收、分散、代谢和排泄(ADME)药理学研究;细胞培养;药物递送研究;细胞冻存。
Albumin human has been used:
  • to study its adsorption process on model mica surface at pH 3.5 using the atomic force microscopy (AFM) and in situ streaming potential measurements
  • to study its proteolytic activities under reducing conditions
  • in the medium for stem cell cultivation

生化/生理作用

Albumin is a binding and transport protein that serves as a protein repository and a carrier for amino acids. Albumin binding dissolves the biomolecules in blood and ensures its effective transport. This also prevents the loss of substance through excretion. Pathological conditions like vasculitis, lymphangiectasia, glomerulonephritis, and hepatic sinusoidal hypertension might result in hypoalbuminemia. This product can be used in the pharmaceutical industry as a drug excipient and to coat medical devices.
白蛋白是可见于动物体液和组织及部分植物种子的一类可溶性单体蛋白。 血清白蛋白可作为类固醇、脂肪酸和甲状腺激素的载体蛋白。 血清白蛋白在调节血液的胶体渗透压方面也至关重要。

分析報告

经过内毒素检测

其他說明

更多信息参见人血清白蛋白

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Autoreactivity against Denatured Type III Collagen Is Significantly Decreased in Serum from Patients with Cancer Compared to Healthy Controls.
Jensen, et al.
International Journal of Molecular Sciences, 24 (2023)
Marta Kujda et al.
Colloids and surfaces. B, Biointerfaces, 127, 192-199 (2015-02-14)
Recombinant human serum albumin (rHSA) in monomeric state is widely used in pharmaceutical industry as a drug excipient and for preparing coatings for medical devices. In this work the adsorption process of rHSA on model mica surface at pH 3.5
Dmitry Kryndushkin et al.
Pharmaceutical research, 33(2), 526-539 (2015-10-27)
Ascorbic acid has been considered as a potential radical scavenging excipient for pharmaceutical formulations. However, under certain circumstances, ascorbic acid can generate reactive oxygen species via redox cycling. The objective of this study was to investigate ascorbic acid-induced oxidative carbonylation
Dmitry Kryndushkin et al.
Pharmaceutical research, 34(4), 765-779 (2017-02-06)
Protein carbonylation is an irreversible modification of Lys, Arg, Thr and Pro amino acids under conditions of oxidative stress. Previous studies have reported specific carbonylated residues in purified recombinant albumins, albeit with a lack of agreement between the studies. Currently
Veronica Liv Andersen et al.
Theranostics, 9(9), 2662-2677 (2019-05-28)
Rationale: Within the field of personalized medicine there is an increasing focus on designing flexible, multifunctional drug delivery systems that combine high efficacy with minimal side effects, by tailoring treatment to the individual. Methods: We synthesized a chemically stabilized ~4

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