8.52035

Fmoc-Glu-OtBu

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• 别名: Fmoc-Glu-OtBu, N-α-Fmoc-L-glutamic acid α-t.-butyl ester
• 经验公式（希尔记法）: C₂₄H₂₇NO₆
• CAS号: 84793-07-7
• 分子量: 425.47
• MDL號碼: MFCD00065648
• 分類程式碼代碼: 12352209
• NACRES: NA.22

属性

• 产品名称: Fmoc-Glu-OtBu, Novabiochem^®
• 品質等級: 200
• 產品線: Novabiochem^®
• 化驗: ≥95.0% (acidimetric); ≥98% (TLC); ≥99.0% (HPLC)
• 形狀: powder
• 反應適用性: reaction type: Fmoc solid-phase peptide synthesis
• 製造商／商標名: Novabiochem^®
• mp: 105-110 °C
• 應用: peptide synthesis
• 官能基: carboxylic acid
• 儲存溫度: 2-30°C
• SMILES 字串: N([C@@H](CCC(=O)O)C(=O)OC(C)(C)C)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C24H27NO6/c1-24(2,3)31-22(28)20(12-13-21(26)27)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,26,27)/t20-/m0/s1
• InChI 密鑰: GOPWHXPXSPIIQZ-FQEVSTJZSA-N

说明

一般說明

Selectively protected building block for library synthesis or the preparation of γ-glutamyl peptides by Fmoc SPPS. After condensation of the side-chain carboxy with an appropriate amine or alcohol, the γ-amino and carboxy functions can be selectively unmasked with 20% piperidine in DMF and 50% TFA in DCM respectively, facilitating the synthesis of branched esters, amides, lactams and lactones containing the glutamyl unit.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

應用

• Discovery of novel OXM-based glucagon-like peptide 1 (GLP-1)/glucagon receptor dual agonists: Research utilized Fmoc-Glu-OtBu for the synthesis of novel dual agonists, underlining its application in developing treatments for metabolic disorders (X Zhang, Y Cai, et al. - Peptides, 2023).
• Engineering a potent and long-acting GLP-1/Y2 receptor dual agonist: Fmoc-Glu-OtBu was used in the synthesis of a dual agonist, showcasing its utility in pharmaceutical developments for diabetes and obesity (J Xu, S Wang, et al. - Peptides, 2023).

聯結

Replaces: 04-12-1075

分析報告

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 95.0 %
Water (K. F.): ≤ 1.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable