8.22339

Phosphoryl chloride

for synthesis

• 别名: Phosphoryl chloride, Phosphorus oxide trichloride, Phosphorus oxychloride
• CAS号: 10025-87-3
• 分子量: 153.33
• MDL编号: MFCD00011443
• UNSPSC代码: 12352101
• EC索引号: 233-046-7
• NACRES: NA.22

属性

• 等级: for synthesis; synthesis grade
• 质量水平: 200
• 蒸汽压: 36 hPa ( 20 °C)
• 方案: ≥99.0% (argenometric)
• 表单: liquid
• 效能: 36 mg/kg LD₅₀, oral (Rat)
• dilution: (for synthesis)
• pH值（酸碱度）: 1.0 (25 °C, 5 g/L in H₂O)
• 沸点: 105.3 °C/1013 hPa
• mp: 1-2 °C
• 密度: 1.68 g/cm³ at 20 °C (DIN 51757)
• 储存温度: 2-30°C
• SMILES字符串: [P](=O)(Cl)(Cl)Cl
• InChI: 1S/Cl3OP/c1-5(2,3)4
• InChI key: XHXFXVLFKHQFAL-UHFFFAOYSA-N

说明

一般描述

for synthesis

应用

Phosphoryl chloride is a strong Lewis acid that can be used as:

• A phosphorylating agent for the selective phosphorylation of alcohols, amines, and thiols.
• A dehydrating agent for alcohols, amides, and cyanohydrins.
• A reagent to synthesize Vilsmeier reagent for Vilsmeier-Haack formylation reactions.
• A chlorinating agent for the chlorination of heterocyclic compounds.
• A reagent to prepare dihydroisoquinolines and isoquinolines by cyclization of N-β-phenylethyl amides via Bischler-Napieralski reaction.

分析说明

Assay (argentometric)≥ 99.0 %Density (d 20 °C/ 4 °C)1.673 - 1.677Identity (IR)passes test

安全信息

• 象形图: GHS05,GHS06,GHS08
• 警示用语：: Danger
• 危险声明: H302 - H314 - H330 - H372
• 预防措施声明: P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P314
• 危险分类: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1 - STOT RE 1 Inhalation
• 靶器官: Respiratory Tract
• 补充剂危害: EUH014 - EUH029
• 储存分类代码: 6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable