616461
TGF-β RI激酶抑制剂VI，SB431542
TGF-β RI Kinase Inhibitor VI, SB431542, CAS 301836-41-9, is a cell-permeable inhibitor of SMAD2 phosphorylation. Inhibits the activity of ALK4 and ALK5 (IC₅₀ = 140 nM and 94 nM, respectively).
别名:
TGF-β RI激酶抑制剂VI，SB431542, 4-[4-（3,4-亚甲二氧基苯基）-5-（2-吡啶基）-1H-咪唑-2-基]苯甲酰胺，二水合物，4-[4-（1,3-苯并二唑-5-基）-5-（2-吡啶基）-1H-咪唑-2-基]苯甲酰胺，二水合物，SB-431542
登录查看公司和协议定价
所有图片(1)
About This Item
推荐产品
品質等級
化驗
≥97% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
off-white
溶解度
ethanol: 10 mg/mL
DMSO: 100 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChI 密鑰
FHYUGAJXYORMHI-UHFFFAOYSA-N
一般說明
一种细胞渗透性三芳基咪唑化合物，经证明可有效抑制NIH 3T3细胞中组成性活性ALK4、ALK5或ALK7的载体介导表达后的细胞Smad2磷酸化（10 µM抑制剂抑制>90%），而在表达活性ALK1、2、3或6的NIH 3T3培养物中，TGF-βⅠ型受体的其他成员对Smad1磷酸化几乎没有影响。当在无细胞激酶分析中直接测试时，SB431542被证明能有效抑制ALK4和ALK5的活性（IC50分别为140 nM和94 nM），而对包括ALK2和ALK6在内的24种其他激酶（IC50在10 µM ATP存在下为≥10 µM）没有效力或大大降低效力。据报道，当与PD0325901（目录号444966）和噻唑维文（目录号420220）一起使用时，4-TF诱导的成纤维细胞培养产生人类IPSC的效率提高了>200倍。
包裝
用惰性气体包装
警告
毒性：标准处理（A）
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Xiaomin Liu et al.
Stem cell research & therapy, 13(1), 198-198 (2022-05-14)
Mammalian lens regeneration holds great potential as a cataract therapy. However, the mechanism of mammalian lens regeneration is unclear, and the methods for optimization remain in question. We developed an in vitro lens regeneration model using mouse capsular bag culture
Ranjay Jayadev et al.
Science advances, 8(20), eabn2265-eabn2265 (2022-05-19)
Basement membranes (BMs) are ubiquitous extracellular matrices whose composition remains elusive, limiting our understanding of BM regulation and function. By developing a bioinformatic and in vivo discovery pipeline, we define a network of 222 human proteins and their animal orthologs
Antonella Muscella et al.
Journal of neurochemistry, 153(4), 525-538 (2019-11-16)
Following peripheral nerve injury, remnant Schwann cells adopt a migratory phenotype and remodel the extracellular matrix allowing axonal regrowth. Although much evidence has demonstrated that TGF-β1 promotes glioma cell motility and induces the expression of extracellular matrix proteins, the effects
Zachary T Hilt et al.
Circulation research, 128(5), 655-669 (2021-01-30)
Circulating monocytes can have proinflammatory or proreparative phenotypes. The endogenous signaling molecules and pathways that regulate monocyte polarization in vivo are poorly understood. We have shown that platelet-derived β2M (β-2 microglobulin) and TGF-β (transforming growth factor β) have opposing effects
Nicola Gritti et al.
Development (Cambridge, England), 148(18) (2021-09-09)
Recent years have seen a dramatic increase in the application of organoids to developmental biology, biomedical and translational studies. Organoids are large structures with high phenotypic complexity and are imaged on a wide range of platforms, from simple benchtop stereoscopes
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门