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S4317

Sigma-Aldrich

SB 431542 水合物

≥98% (HPLC), powder, inhibits activation of SMAD proteins

别名:

4-(5-苯并[1,3]二唑-5-基-4-吡啶-2-基-1H-咪唑-2-基)-苯甲酰胺 水合物, 4-[4-(1,3-苯并二唑-5-基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯甲酰胺 水合物, 4-[4-(3,4-亚甲二氧基苯基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯甲酰胺 水合物

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About This Item

经验公式（希尔记法）:
C22H16N4O3 · xH2O
CAS号:
301836-41-9
分子量:
384.39 (anhydrous basis)
MDL號碼:
MFCD11045982
分類程式碼代碼:
51111800
PubChem物質ID:
24724609
NACRES:
NA.77

product name

SB 431542 水合物, ≥98% (HPLC), powder

化驗

≥98% (HPLC)

形狀

powder

溶解度

DMSO: soluble 10 mg/mL
H2O: insoluble

起源

GlaxoSmithKline

儲存溫度

−20°C

SMILES 字串

O.NC(=O)c1ccc(cc1)-c2nc(-c3ccc4OCOc4c3)c([nH]2)-c5ccccn5

InChI

1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2

InChI 密鑰

WQUIJVKNPYBZOF-UHFFFAOYSA-N

應用

SB-431542被用于研究结直肠肿瘤细胞中血小板衍生生长因子受体B表达与TGF-β途径激活的相关性。它被用于研究TGF-β信号传导在调节细胞外基质 和成肌细胞分化中的作用。

生化／生理作用

SB-431542可抑制TGF-β介导的SMAD蛋白活化、胶原和纤连蛋白表达、细胞增殖和细胞运动。它不抑制因血清或应激而激活的激酶，如ERK、p38或JNK。
转化生长因子-β超家族I型激活素受体样激酶（ALK）受体的有效和选择性抑制剂。

特點和優勢

该化合物由 GlaxoSmithKline开发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。

法律資訊

根据Glaxo­Smith­Kline协议出售，用于研究目的

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.
Isogaya K, Koinuma D, Tsutsumi S, et al.
Cell Research, 24(8), 994-1008 (2014)
N J Laping et al.
Molecular pharmacology, 62(1), 58-64 (2002-06-18)
Transforming growth factor beta1 (TGF-beta1) is a potent fibrotic factor responsible for the synthesis of extracellular matrix. TGF-beta1 acts through the TGF-beta type I and type II receptors to activate intracellular mediators, such as Smad proteins, the p38 mitogen-activated protein
Yu Zhang et al.
Frontiers in cell and developmental biology, 8, 573028-573028 (2020-10-13)
BMP2 is a critical factor that is involved in the processes of embryo implantation and uterine decidualization. The expression of cyclooxygenase (COX) and subsequent prostaglandin E2 (PGE2) production are critical for successful pregnancy. However, it is not clear whether BMP2
Paola Bendinelli et al.
International journal of molecular sciences, 20(10) (2019-05-28)
Hepatocyte growth factor (HGF) and transforming growth factor β1 (TGFβ1) are biological stimuli of the micro-environment which affect bone metastasis phenotype through transcription factors, but their influence on the growth is scarcely known. In a xenograft model prepared with 1833
Ernst J A Steller et al.
Neoplasia (New York, N.Y.), 15(2), 204-217 (2013-02-27)
In epithelial tumors, the platelet-derived growth factor receptor B (PDGFRB) is mainly expressed by stromal cells of mesenchymal origin. Tumor cells may also acquire PDGFRB expression following epithelial-to-mesenchymal transition (EMT), which occurs during metastasis formation. Little is known about PDGFRB
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