494105

Neuroprotectant, OBA-09

A brain-permeable ester of pyruvate and salicylic acid that exhibits anti-oxidative and anti-excitotoxic properties.

• 别名: Neuroprotectant, OBA-09
• 经验公式（希尔记法）: C₁₀H₈O₅
• CAS号: 856095-68-6
• 分子量: 208.17
• MDL號碼: MFCD24445086
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥99% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 50 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(C(C)=O)OC1=CC=CC=C1C(O)=O

说明

一般說明

A brain-permeable ester of pyruvate and salicylic acid that exhibits anti-oxidative and anti-excitotoxic properties.

A brain-permeable ester of pyruvate and salicylic acid that exhibits anti-oxidative and anti-excitotoxic properties. Following its uptake by the brain tissue, it releases pyruvate and salicylic acid via ester hydrolysis (t_1/2 of 43 min in serum). Exerts strong neuroprotective effects in the post-ischemic brain and significantly reduces infarct volume (27% and 65% reduction in 6 and 12 hours following i.v. administration of 10 mg/kg in a rat model). Also, blocks Zn²⁺-induced neuronal cell death. Its neuroprotective effects are attributed to its ability to prevent NAD- and ATP-depletion in post-ischemic brain and suppression of NF-κB activity by reducing IκB-α degradation.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Kim, S.W., et al. 2011. Mol. Pharmacol.79, 220.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable