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品質等級
化驗
≥97% (by Assay)
形狀
crystalline powder
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
顏色
gray to off-white
溶解度
water: 2.5 mg/mL
methanol: 35 mg/mL
ethanol: soluble
運輸包裝
ambient
儲存溫度
10-30°C
InChI
1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)
InChI 密鑰
WIIZWVCIJKGZOK-UHFFFAOYSA-N
一般說明
通过与50S核糖体亚基结合来抑制RNA到蛋白质的翻译，从而阻止肽基转移酶反应的合成抑菌抗生素。氯霉素抗性由抗性基因cat编码，其产物氯霉素乙酰转移酶可通过乙酰化使抗生素失活。通常以30-50 µg/ml用于筛选带有氯霉素抗性的大肠杆菌。
通过阻断核糖体上肽基转移酶反应来抑制RNA翻译的合成抑菌抗生素。
生化／生理作用
功效：≥970 µg/mg
首要靶标
RNA的翻译
RNA的翻译
其他說明
Lech, K., and Brent, R. 1995. in Current Protocols in Mol.Biol. Vol. 1, (Ausubel, F.M., et al., Eds.)John Wiley & Sons, New York.
Lu, J., and Jiang, C. 1993.Biochem.Biophys.Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993.Virol.197, 35.
Holt, J.T. 1992.Ann.N.Y.Acad.Sci.660, 88.
Maniatis, T., et al. 1989.In Molecular Cloning, A Laboratory Manual, Second Edition.Cold Spring Harbor, NY, p. 1.6, A.6.
Lu, J., and Jiang, C. 1993.Biochem.Biophys.Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993.Virol.197, 35.
Holt, J.T. 1992.Ann.N.Y.Acad.Sci.660, 88.
Maniatis, T., et al. 1989.In Molecular Cloning, A Laboratory Manual, Second Edition.Cold Spring Harbor, NY, p. 1.6, A.6.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險聲明
危險分類
Carc. 2 - Eye Dam. 1 - Repr. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
其他客户在看
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eLife, 9 (2020-01-30)
Predicting antibiotic efficacy within microbial communities remains highly challenging. Interspecies interactions can impact antibiotic activity through many mechanisms, including alterations to bacterial physiology. Here, we studied synthetic communities constructed from the core members of the fruit fly gut microbiota. Co-culturing
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PLoS biology, 18(1), e3000567-e3000567 (2020-01-28)
Cell- and tissue-level processes often occur across days or weeks, but few imaging methods can capture such long timescales. Here, we describe Bellymount, a simple, noninvasive method for longitudinal imaging of the Drosophila abdomen at subcellular resolution. Bellymounted animals remain
Heidi A Arjes et al.
Current biology : CB, 30(6), 1011-1022 (2020-02-16)
The presence or absence of oxygen in the environment is a strong effector of cellular metabolism and physiology. Like many eukaryotes and some bacteria, Bacillus subtilis primarily utilizes oxygen during respiration to generate ATP. Despite the importance of oxygen for
Maxime Louet et al.
eLife, 10 (2021-09-04)
There is increasing support for water molecules playing a role in signal propagation through G protein-coupled receptors (GPCRs). However, exploration of the hydration features of GPCRs is still in its infancy. Here, we combined site-specific labeling with unnatural amino acids
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