推荐产品
等級
certified reference material
品質等級
形狀
liquid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 1 mL
製造商／商標名
Cerilliant®
濃度
1.0 mg/mL in methanol (as free base)
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
clinical testing
形式
single component solution
儲存溫度
−20°C
SMILES 字串
Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13
InChI
1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H
InChI 密鑰
SHAYBENGXDALFF-UHFFFAOYSA-N
基因資訊
human ... SLC6A2(6530) , SLC6A4(6532)
一般說明
去甲替林是第二代三环类抗抑郁药（TCA），商品名为Sensoval、Aventyl和Pamelor，用于治疗重度抑郁症。®®去甲替林也是TCA阿米替林的活性代谢物。该认证Snap-N-Spike®溶液适合通临床毒理学、法医分析、尿液药物测试或药物监测中的LC/MS或GC/MS应用。
應用
- 神经药理学研究：一项研究探讨了抗抑郁药（包括盐酸去甲替林）与心理治疗相结合的有效性。本研究强调了其在治疗心理健康障碍中的作用，展示了该化合物在神经药理学研究中的重要性，及其在神经递质研究中进一步探索的潜力 (Alemi et al., 2024）。
- 周围神经病变治疗：研究人员评估了盐酸去甲替林治疗糖尿病周围神经病变的疗效，重点介绍了其超越传统抗抑郁药物应用的治疗益处。本研究强调了其在生化检测中的实用性，目的在于让我们了解其对神经生理学途径的作用机制（Straczek et al., 2024）。
法律資訊
Aventyl is a registered trademark of Eli Lilly and Co.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Pamelor is a registered trademark of Mallinckrodt Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相關產品
产品编号
说明
价格
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes,Central nervous system
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
其他客户在看
Abdennasser Bardai et al.
European heart journal, 34(20), 1506-1516 (2013-02-22)
Non-cardiac drugs that impair cardiac repolarization (electrocardiographic QT prolongation) are associated with an increased sudden cardiac arrest (SCA) risk. Emerging evidence suggests that non-cardiac drugs that impair cardiac depolarization and excitability (electrocardiographic QRS prolongation) also increase the risk for SCA.
The march of the masses.
Russell P Grant
Clinical chemistry, 59(6), 871-873 (2013-04-18)
Hongxia Li et al.
Environmental toxicology and chemistry, 32(3), 509-516 (2013-01-03)
Amitriptyline and nortriptyline are widely used tricyclic antidepressant drugs. They have been detected in wastewater, surface runoff, and effluents from sewage treatment plants. As such, they could potentially reach agriculture land through the application of municipal biosolids or reclaimed water.
Response to "SSRIs: a premature burial".
P Weeke et al.
Clinical pharmacology and therapeutics, 93(3), 235-235 (2013-01-10)
Karim Malki et al.
Pharmacogenetics and genomics, 22(11), 765-776 (2012-10-03)
Monoaminergic imbalances play a role in the pathogenesis of depression and most common antidepressant drugs act on monoamine neurotransmitters. However, the lag time between restoring neurochemical balance and symptom improvement suggests that the response to drugs involves complex biological events
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