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Merck

N7261

Sigma-Aldrich

去甲替林 盐酸盐

≥98% (HPLC), powder

别名:

3-(10,11-二氢-5 H -二苯并[ a , d ] 环庚烯-5-亚基)- N -甲基-1-丙胺 盐酸盐, 去甲阿米替林 盐酸盐

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About This Item

经验公式(希尔记法):
C19H21N · HCl
CAS号:
分子量:
299.84
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.77

方案

≥98% (HPLC)

表单

powder

颜色

white to off-white

溶解性

ethanol: 100 mg/mL
H2O: soluble

创始人

Eli Lilly

SMILES字符串

Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H

InChI key

SHAYBENGXDALFF-UHFFFAOYSA-N

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生化/生理作用

与 5-羟色胺转运体 (K i = 161 nM) 相比,三环类抗抑郁药是去甲肾上腺素转运体 (K i = 3.4 nM) 的一种更强效的抑制剂。5-HT 2 5-羟色胺受体拮抗剂。

特点和优势

该化合物收录于 受体分类和信号转导手册的《生物胺转运体 》页面。想要浏览手册的其他页面, 请单击此处
该化合物由Eli Lilly开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Antidepressants targeting Na(+)/Cl(-)-coupled neurotransmitter uptake define a key therapeutic strategy to treat clinical depression and neuropathic pain. However, identifying the molecular interactions that underlie the pharmacological activity of these transport inhibitors, and thus the mechanism by which the inhibitors lead
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Clinical chemistry, 59(6), 920-927 (2013-02-22)
The addition of a calibration curve with every run is both time-consuming and expensive for clinical mass spectrometry assays. We present alternative calibration strategies that eliminate the need for a calibration curve except as required by laboratory regulations. We measured
SSRIs: a premature burial.
K Jensen
Clinical pharmacology and therapeutics, 93(3), 234-235 (2012-12-20)
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The Cochrane database of systematic reviews, 12, CD009670-CD009670 (2012-12-14)
Effective pharmacotherapies are available to help people who are trying to stop smoking, but quitting can still be difficult and providing higher levels of behavioural support may increase success rates further. To evaluate the effect of increasing the intensity of

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