902691

Hydroxy-PEG5-t-butyl ester

• 别名: tert-Butyl 1-hydroxy-3,6,9,12,15-pentaoxaoctadecan-18-oate, HO-PEG5-CO-OtBu
• 经验公式（希尔记法）: C₁₇H₃₄O₈
• CAS号: 850090-09-4
• 分子量: 366.45
• MDL號碼: MFCD20926402
• 分類程式碼代碼: 51171641

属性

• 化驗: ≥95%
• 形狀: liquid
• 反應適用性: reagent type: cross-linking reagent
• 折射率: n/D 1.448
• 密度: 1.071
• 官能基: ester; hydroxyl
• 儲存溫度: −20°C
• SMILES 字串: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCO

说明

應用

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Hydroxy-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

其他說明

Synthesis and Application of Poly(phenylene Ethynylene)s for Bioconjugation: A Conjugated Polymer-Based Fluorogenic Probe for Proteases

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable