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Merck
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文件

667005

Sigma-Aldrich

(R)-(+)-3,3,3-三氟-1,2-环氧丙烷

97%

别名:

(R)-(+)-2-三氟甲基环氧乙烷

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About This Item

经验公式（希尔记法）:
C3H3F3O
CAS号:
143142-90-9
分子量:
112.05
MDL號碼:
MFCD08276876
分類程式碼代碼:
12352005
PubChem物質ID:
24884878
NACRES:
NA.22

化驗

97%

折射率

n20/D <1.300

bp

25-32 °C

密度

1.294 g/mL at 25 °C

儲存溫度

2-8°C

SMILES 字串

FC(F)(F)[C@H]1CO1

InChI

1S/C3H3F3O/c4-3(5,6)2-1-7-2/h2H,1H2/t2-/m1/s1

InChI 密鑰

AQZRARFZZMGLHL-UWTATZPHSA-N

相关类别

應用

(R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane can be used as a substrate to synthesize:
  • Substituted trifluoro amino propanols, which are found to be potent inhibitors of cholesteryl ester transfer protein.
  • (2R) Trifluoro-(methoxybenzyloxy)-propanol (chiral glycol) by reacting with 4-methoxybenzyl alcohol in the presence of NaH. Chiral glycol intermediate is further utilized for the preparation of trifluoromethyl glycol carbamates as potential monoacylglycerol lipase (MAGL) inhibitors.

象形圖

Flame
GHS02

訊號詞

Danger

危險聲明

H224

防範說明

P210 - P403 + P233

危險分類

Flam. Liq. 1

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 3

閃點（°F）

-14.8 °F

閃點（°C）

-26 °C

個人防護裝備

Eyeshields, Faceshields, Gloves

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Discovery of trifluoromethyl glycol carbamates as potent and selective covalent monoacylglycerol lipase (MAGL) inhibitors for treatment of neuroinflammation
McAllister LA, et al.
Journal of Medicinal Chemistry, 61(7), 3008-3026 (2018)
Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein
Reinhard EJ, et al.
Journal of Medicinal Chemistry, 46(11), 2152-2168 (2003)
Emily J Reinhard et al.
Journal of medicinal chemistry, 46(11), 2152-2168 (2003-05-16)
A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols is described which potently and reversibly inhibit cholesteryl ester transfer protein (CETP). Starting from the initial lead 1, various substituents were introduced into the 3-phenoxyaniline group to optimize the relative activity for inhibition of

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