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Merck

367532

Sigma-Aldrich

5-氯-1-甲基-4-硝基咪唑

98%

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About This Item

经验公式(希尔记法):
C4H4ClN3O2
CAS号:
分子量:
161.55
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

98%

mp

148-150 °C (lit.)

SMILES 字串

Cn1cnc(c1Cl)[N+]([O-])=O

InChI

1S/C4H4ClN3O2/c1-7-2-6-4(3(7)5)8(9)10/h2H,1H3

InChI 密鑰

OSJUNMSWBBOTQU-UHFFFAOYSA-N

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一般說明

5-Chloro-1-methyl-4-nitroimidazole is an 4-nitroimidazole derivative.

應用

5-Chloro-1-methyl-4-nitroimidazole (CMNI) is suitable for use in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells by CMNI. It may be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine)palladium(II), K2CO3 and tetrabutylammonium bromide.

相關產品

产品编号
说明
价格

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Rapid-mix studies on the anomalous radiosensitization of mammalian cells by 5-chloro-1-methyl-4-nitromidazole.
M E Watts et al.
International journal of radiation biology and related studies in physics, chemistry, and medicine, 38(6), 673-675 (1980-12-01)
J Watras et al.
Neoplasma, 34(3), 253-259 (1987-01-01)
The transplantable rhabdomyosarcoma in WAG/Rij rats was used to test the in vivo effectiveness of 1-methyl-2-chloro-4-nitroimidazole (P13) and its analog 1-(2-hydroxy-3-methoxy-propyl)-2-chloro-4-nitroimidazole (P40) as tumor-cell radiosensitizers after their i.p. administration at low doses. The results indicate that both compounds administered repeatedly
Are ortho-substituted 4-nitroimidazoles a new generation of radiation-induced arylating agents?
E D Clarke et al.
International journal of radiation biology and related studies in physics, chemistry, and medicine, 37(4), 463-468 (1980-04-01)
The kinetics of the reaction of 'anomalous' 4-nitroimidazole radiosensitizers with thiols.
P Wardman
International journal of radiation biology and related studies in physics, chemistry, and medicine, 41(2), 231-235 (1982-02-01)
Occupational allergic contact dermatitis from 5-chloro-1-methyl-4-nitroimidazole.
R Jolanki et al.
Contact dermatitis, 36(1), 53-54 (1997-01-01)

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