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Merck

218707

Sigma-Aldrich

环磷酰胺 一水合物

≥98%

别名:

2-[双(2-氯乙基)氨基]四氢-2H-1,3,2-噁磷-2-氧化物, Cytoxan

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About This Item

经验公式(希尔记法):
C7H15Cl2N2O2P · H2O
CAS号:
分子量:
279.10
Beilstein:
4678992
EC號碼:
MDL號碼:
分類程式碼代碼:
12352103

化驗

≥98%

mp

49-51 °C (lit.)

SMILES 字串

[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1

InChI

1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2

InChI 密鑰

PWOQRKCAHTVFLB-UHFFFAOYSA-N

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生化/生理作用

环磷酰胺是一种广泛用于癌症化疗的具有细胞毒性的氮芥衍生物。它可与 DNA 交联、导致链断裂并诱导突变。其临床活性与乙醛脱氢酶 1 (ALDH1) 的活性降低相关。

特點和優勢

癌症研究工具。

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