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ALD00602

Sigma-Aldrich

(–)-PSI Reagent

95%

Synonyme(s) :

(2S,3aS,6R,7aS)-3a-Methyl-2-((perfluorophenyl)thio)-6-(prop-1-en-2-yl)hexahydrobenzo[d][1,3,2]oxathiaphosphole 2-sulfide, (–)-Ψ, Phosphorus-Sulfur Incorporation Reagent

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About This Item

Formule empirique (notation de Hill):
C16H16F5OPS3
Numéro CAS:
2245335-70-8
Poids moléculaire :
446.46
Code UNSPSC :
12352101
Nomenclature NACRES :
NA.22

Pureté

95%

Forme

powder or crystals

Pf

103-107 °C

Application

Air- and moisture-tolerant, this (-)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (+)-PSI Reagent, is also available (cat# ALD00604).
The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).

Learn more about PI and PSI reagents

Autres remarques

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

PSI on OpenFlask

Informations légales

PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

88185

Tetrazole solution, suitable for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile

302309

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite, Cl 13.5-15.5 %

416436

Dibenzyl N,N-diisopropylphosphoramidite, technical grade, 90%

392561

Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite, 97%

305995

2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphorodiamidite, 97%

419362

Di-tert-butyl N,N-diisopropylphosphoramidite, 95%

760838

Allyl tetraisopropylphosphorodiamidite, 95%

760811

Bis[2-(trimethylsilyl)ethyl] N,N-diisopropylphosphoramidite, 96%

766305

Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite, 95%

ALD00604

(+)-PSI Reagent, 95%

ALD00613

PSI2

ALD00617

(−)-PI Reagent, ≥95%

ALD00618

(+)-PI Reagent, ≥95%

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
MKCW0630
MKCT5558
MKCK2384
MKCM3402
MKCL7375

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Kyle W Knouse et al.
Science (New York, N.Y.), 361(6408), 1234-1238 (2018-08-04)
Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation of this chiral motif has long been hampered by the systemic

Articles

PI and PSI – Chiral phosphorus incorporation harnessing the potential of P(V)

PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.

PI and PSI – Chiral phosphorus incorporation harnessing the potential of P(V)

PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.

PI and PSI – Chiral phosphorus incorporation harnessing the potential of P(V)

PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.

PI and PSI – Chiral phosphorus incorporation harnessing the potential of P(V)

PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.

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