D39002

1,2-Dibromobenzene

98%

• Synonyme(s) : o-Dibromobenzene
• Formule empirique (notation de Hill): C₆H₄Br₂
• Numéro CAS: 583-53-9
• Poids moléculaire : 235.90
• Numéro Beilstein : 970241
• Numéro CE : 209-507-3
• Numéro MDL: MFCD00000057
• Code UNSPSC : 12352100
• ID de substance PubChem : 24893794
• Nomenclature NACRES : NA.22

Propriétés

• Densité de vapeur: 8.2 (vs air)
• Niveau de qualité: 200
• Pureté: 98%
• Forme: liquid
• Indice de réfraction: n20/D 1.611 (lit.)
• Point d'ébullition: 224 °C (lit.)
• Pf: 4-6 °C (lit.)
• Densité: 1.956 g/mL at 25 °C (lit.)
• Chaîne SMILES: Brc1ccccc1Br
• InChI: 1S/C6H4Br2/c7-5-3-1-2-4-6(5)8/h1-4H
• Clé InChI: WQONPSCCEXUXTQ-UHFFFAOYSA-N

Description

Description générale

1,2-Dibromobenzene, also known as o-Dibromobenzene, is an aromatic halogenated hydrocarbon commonly used as a precursor in various organic synthesis reactions based on the intermediate formation of benzynes.

Application

• Selective Covalent Capture of Collagen Triple Helices with Minimal Protecting Group Strategy: This study details the use of Rink Amide MBHA resin for capturing collagen triple helices, highlighting its efficiency in solid-phase synthesis (JDH Le Tracy Yu, 2020).


• Solid phase peptide synthesis: new resin and new protecting group: Introduction of a novel resin, Fmoc-Rink-Amide PEG Octagel, showcasing its application in peptide synthesis (S Ramkisson, 2018).


• Development of a novel, automated, robotic system for rapid, high-throughput, parallel, solid-phase peptide synthesis: This paper discusses the utilization of Rink Amide MBHA resin in developing an automated system for peptide synthesis (K Kiss et al., 2023).


• Synthesis of Peptoids Containing Multiple Nhtrp and Ntrp Residues: A Comparative Study of Resin, Cleavage Conditions and Submonomer Protection: The study compares different resins including Rink Amide MBHA, analyzing their efficacy in peptoid synthesis (A Lone et al., 2020).

It is also used as a key reactant in the synthesis of:

• diborylbenzenes via palladium-catalyzed borylation of bromobenzenes
• o,o′-tri- and -tetrasubstituted biphenyls via aryne cross-coupling reaction

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335,H411
• Conseils de prudence: P273 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 197.6 °F - closed cup
• Point d'éclair (°C): 92 °C - closed cup
• Équipement de protection individuelle: Eyeshields, Gloves, type ABEK (EN14387) respirator filter