Unfortunately, a GMP version of this item is not currently offered. This is the only Cyclosporin H product available at this time.
SML1575
Cyclosporin H
≥97% (HPLC)
Sinónimos:
1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv, 5-(N-Methyl-D-valine)-Cyclosporin A
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1 MG
122,00 €
5 MG
490,00 €
122,00 €
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1 MG
122,00 €
5 MG
490,00 €
About This Item
Fórmula empírica (notación de Hill):
C62H111N11O12
Número de CAS:
Peso molecular:
1202.61
Código UNSPSC:
51111800
NACRES:
NA.77
122,00 €
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origen biológico
Tolypocladium inflatum
Nivel de calidad
Ensayo
≥97% (HPLC)
Formulario
powder
actividad óptica
[α]/D -100 to -115°, c = 0.5 in methanol
condiciones de almacenamiento
desiccated
protect from light
color
white to beige
temp. de almacenamiento
−20°C
cadena SMILES
N1([C@@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N(C(C(=O)N[C@H](C(=O)N(CC(=O)N([C@H](C1=O)CC(C)C)C)C)CC)[C@H](O)[C@@H](C\C=C\C)C)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)C
InChI
1S/C63H113N11O12/c1-26-28-29-41(15)53(76)52-56(79)66-44(27-2)58(81)67(18)34-49(75)68(19)46(31-36(5)6)60(83)72(23)50(39(11)12)62(85)69(20)45(30-35(3)4)55(78)64-42(16)54(77)65-43(17)57(80)70(21)47(32-37(7)8)59(82)71(22)48(33-38(9)10)61(84)73(24)51(40(13)14)63(86)74(52)25/h26,28,35-48,50-53,76H,27,29-34H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)/b28-26+/t41-,42+,43-,44+,45+,46+,47+,48+,50-,51+,52?,53-/m1/s1
Clave InChI
BQQHPBPTWWXRMU-SXHXJWHLSA-N
Aplicación
Cyclosporin H has been used:
- to pre-culture the lineage depleted murine Flt3ITDIDH2R140Q BM cells for transduction[1]
- as a formyl peptide receptor (FPR) antagonist to study the role of FPR1 in calcium mobilization in polymorphonuclear leukocytes (PMNs)[2]
- as one of the small molecules to study its effect on the homology-directed repair (HDR) editing efficiency in human-induced pluripotent stem cells (iPSCs) and T cells[3]
Acciones bioquímicas o fisiológicas
Cyclosporin H is a selective inhibitor of formyl peptide receptor-1 (FPR-1) and formyl peptide-induced superoxide formation in neutrophils.
Cyclosporin H is a selective inhibitor of formyl peptide receptor-1 (FPR-1) and formyl peptide-induced superoxide formation in neutrophils. Cyclosporin H does not bind cyclophilin or evoke an immunosuppressant response. Cyclosporin H has been reported to inhibit tumor promoting phorbol ester TPA/PMA in mouse skin cells and to inhibit calcium/calmodulin-dependent EF-2 phosphorylation.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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シクロスポリンHのGMPグレードはありますか？
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This product is not tested for use in any specific application and does not include a protocol. It may be helpful to review the Peer Reviewed Papers section of the product page.
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