The molecular weight of this compound is 540.70 Daltons. This product is tested for solubility in DMSO. The minimum solubility specification is 25 mg/mL. A review of past lots reveals rates ranging from 40 - 46 mg/ml in DMSO. Please see the link below to access a sample or lot-specific Certificate of Analysis:
https://www.sigmaaldrich.com/product/sigma/sml1175#product-documentation
SML1175
Romidepsin
≥98% (HPLC), powder, histone deacetylase inhibitor
Sinónimos:
Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl] cyclic (35)-disulfide, Depsipeptide, FK228, FR901228, L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide
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1 MG
325,00 €
325,00 €
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1 MG
325,00 €
About This Item
Fórmula empírica (notación de Hill):
C24H36N4O6S2
Número de CAS:
Peso molecular:
540.70
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
325,00 €
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Nombre del producto
Romidepsin, ≥98% (HPLC)
Nivel de calidad
Ensayo
≥98% (HPLC)
Formulario
powder
color
white to beige
solubilidad
DMSO: 25 mg/mL, clear
temp. de almacenamiento
−20°C
cadena SMILES
O=C(N/C(C(N[C@@H](C(C)C)C(O[C@@]1([H])CC2=O)=O)=O)=C\C)[C@@H](CSSCC/C=C/1)NC([C@H](N2)C(C)C)=O
InChI
1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1
Clave InChI
OHRURASPPZQGQM-GCCNXGTGSA-N
Información sobre el gen
human ... HDAC1(3065) , HDAC10(83933) , HDAC11(79885) , HDAC2(3066) , HDAC3(8841) , HDAC4(9759) , HDAC5(10014) , HDAC6(10013) , HDAC7(51564) , HDAC8(55869) , HDAC9(9734)
Acciones bioquímicas o fisiológicas
Romidepsin is a very potent natural prodrug inhibitor of HDAC1 and HDAC2 that is converted to active form by glutathione. Romidepsin has IC50 values of 36 nM and 47 nM for HDAC1 and HDAC2, respectively. Romidepsin kills lymphoma cell lines overexpressing Bcl-2 and Bcl-XL, and has been approved for the treatment for cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma, and a variety of other cancers.
Romidepsin promotes apoptosis, while hindering tumor growth in glioma models.[1]
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
Lot/Batch Number
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How much volume of the solvent do I have to resuspend in it? To get the stock concentration of what? Also what is the molecular weight of the same?
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